Ankur B. Patel

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In the mouse model of Fragile X syndrome, the Fmr1 knock-out, local excitation of layer 4 fast-spiking (FS) inhibitory neurons is robustly decreased by 50%, but the mechanisms mediating this change are unknown. Here, we performed recordings in acutely prepared slices obtained from Fmr1 "mosaic" mice, where Fmr1 is deleted in about half of all neurons, and(More)
Pruning of structural synapses occurs with development and learning. A deficit in pruning of cortical excitatory synapses and the resulting hyperconnectivity is hypothesized to underlie the etiology of fragile X syndrome (FXS) and related autistic disorders. However, clear evidence for pruning in neocortex and its impairment in FXS remains elusive. Using(More)
Both short- and long-term roles for the group I metabotropic glutamate receptor number 5 (mGluR5) have been examined for the regulation of cortical glutamatergic synapses. However, how mGluR5 sculpts neocortical networks during development still remains unclear. Using a single cell deletion strategy, we examined how mGluR5 regulates glutamatergic synaptic(More)
Jay R. Gibson 12 University of Texas, Southwestern Medical Center 13 Department of Neuroscience, Box 9111 14 Dallas, TX 75390-9111 15 Phone: 214-648-5134, Fax: 214-648-1801, Email: Jay.Gibson@UTSouthwestern.edu 16 17 Author Contributions 18 JRG, KMH, and KWL planned and designed experiments. KWL and ABP performed all experiments. 19 KWL analyzed data. JRG(More)
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