Ankit N. Khambhati

Learn More
While modulating neural activity through stimulation is an effective treatment for neurological diseases such as Parkinson's disease and essential tremor, an opportunity for improving neuromodulation therapy remains in automatically adjusting therapy to continuously optimize patient outcomes. Practical issues associated with achieving this include the(More)
The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. However, poor surgical outcome suggests a complex relationship between foci and the surrounding network that drives seizure dynamics. We developed a(More)
In ∼20 million people with drug-resistant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and spread to surrounding tissue, disrupting function in otherwise normal brain regions. To identify network control mechanisms that regulate seizure spread, we developed a novel tool for pinpointing brain regions that facilitate(More)
Horizontal connections in the primary visual cortex have been hypothesized to play a number of computational roles: association field for contour completion, surface interpolation, surround suppression, and saliency computation. Here, we argue that horizontal connections might also serve a critical role for computing the appropriate codes for image(More)
In this issue of Neuron, Grayson et al. (2016) report how inhibition of amygdala impacts amygdalocortical and corticocortical functional connectivity. Their study predicts changes in functional brain topology, induced by pharmacologic modulation of neuroanatomical circuits using designer receptors exclusively activated by designer drugs (DREADDs), through(More)
— In this paper, we study dynamic-flow networks, i.e., networks described by a graph whose weights evolve according to linear differential equations. Further, these linear differential equations depend on the incidence relation of the edges in a node, and possibly nodal dynamics. Because some of these weights and their dependencies may not be accurately(More)
For ≈20 million people with drug-resistant epilepsy, recurring, spontaneous seizures have a devastating impact on daily life. The efficacy of surgical treatment for controlling seizures is hindered by a poor understanding of how some seizures spread to and synchronize surrounding tissue while others remain focal. To pinpoint network regions that regulate(More)
  • 1