Ankit Awasthi

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Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we evaluated mouse models of age-associated memory impairment and amyloid deposition to study transcriptome and cell type-specific epigenome plasticity in the brain and peripheral(More)
Dendritic spines compartmentalize information in the brain, and their morphological characteristics are thought to underly synaptic plasticity. Here we identify copine-6 as a novel modulator of dendritic spine morphology. We found that brain-derived neurotrophic factor (BDNF) - a molecule essential for long-term potentiation of synaptic strength -(More)
Interactions between astrocytes and neurons rely on the release and uptake of glial and neuronal molecules. But whether astrocytic vesicles exist and exocytose in a regulated or constitutive fashion is under debate. The majority of studies have relied on indirect methods or on astrocyte cultures that do not resemble stellate astrocytes found in vivo. Here,(More)
The role of perception in sighted infant motor development is well-established, but what are the processes by which an infant manages to handle the complex high-dimensional visual input? Clearly, the input has to be modeled in terms of lowdimensional codes so that plans may be made in a more abstract space. While a number of computational studies have(More)
While seraching for an object in a scene humans make use various sources of information for narrowing down their search to certain areas which are more probable to have that object. Various sources of ”top down” influences have been investigated in the literature including contexual guidance and appearance based influence to attentional guidance. In our(More)
Facial emotion recognition is one of the most important cognitive functions that our brain performs quite efficiently. State of the art facial emotion recognition techniques are mostly performance driven and do not consider the cognitive relevance of the model. This project is an attempt to look at the task of emotion recognition using deep belief networks(More)
TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons. However, the location and function of TRPV1 in the hippocampus is debated. We found that TRPV1 is expressed in oriens-lacunosum-moleculare (OLM) interneurons in the hippocampus, and promotes excitatory(More)
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