Ankit A Zalavadia

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Introduction: Recently, dried blood spot (DBS) sampling method has turned out to be a promising microsampling technique for use in preclinical studies of animals and humans in order to obtain matrix samples. With this technique, small-molecule PK characterization with LC-MS/MS has become simpler and faster. Blood sample volumes as low as 15-20 ul containing(More)
BACKGROUND Sterile inflammation resulting from myocardial injury activates the NLRP3 inflammasome and amplifies the inflammatory response mediating further damage. METHODS We used 2 experimental models of ischemic injury (acute myocardial infarction [AMI] with and without reperfusion) and a model of nonischemic injury due to doxorubicin 10 mg/kg to(More)
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