Anke ter Harmsel

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Apart from impaired β-oxidation, Pparα-deficient (Pparα) mice suffer from hypoglycemia during prolonged fasting, suggesting alterations in hepatic glucose metabolism. We compared hepatic glucose metabolism in vivo in wild-type (WT) and Pparα mice after a short-term fast, applying novel isotopic methods. After a 9h fast mice were infused with [U-C] glucose,(More)
Glucose-6-phosphatase (G6Pase) is a key enzyme in hepatic glucose metabolism. Altered G6Pase activity in glycogen storage disease and diabetic states is associated with disturbances in lipid metabolism. We studied the effects of acute inhibition of G6Pase activity on hepatic lipid metabolism in nonanesthetized rats. Rats were infused with an inhibitor of(More)
BACKGROUND Dietary fat content influences bile salt metabolism, but quantitative data from controlled studies in humans are scarce. OBJECTIVE The objective of the study was to establish the effect of dietary fat content on the metabolism of primary bile salts. DESIGN The effects of eucaloric extremely low-fat (0%), intermediate-fat (41%; control diet),(More)
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