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Chitosan microspheres loaded with indomethacin were prepared using only aqueous solvents. The influence of formulation variables on indomethacin content in the microspheres and time for release of 66.6% of indomethacin from the microspheres was investigated. Amongst various variables, the indoemthacin:chitosan ratio and amount of crosslinking agent were(More)
OBJECTIVE To assess the practice of complementary feeding (CF) in infants 6 month to 2 year, knowledge of mothers regarding CF, and reasons for inappropriate CF practices. METHODS CF practices were assessed in children aged 6 months to 2 years using semi-structured questionnaire. Demographic profile and mother's knowledge regarding CF was recorded. Cause(More)
Intravenous loading is required to reach therapeutic levels of antiepileptic drugs. Valproate, the drug of choice for most epilepsy, may be a better option than phenytoin. In total, 100 children (aged 3-12 years) with motor focal seizures or generalized seizures (second episode) were randomized to receive valproate (20 mg/kg) or phenytoin (20 mg/kg).(More)
Evidence suggests that carbamazepine affects bone metabolism by altering vitamin D status. We prospectively compared 25-hydroxyvitamin D, parathormone, calcium, phosphorus, and alkaline phosphatase levels at initiation and 6 months of carbamazepine therapy in children, and correlated them with carbamazepine levels. We included 47 children newly diagnosed(More)
Antiepileptic therapy is associated with alteration of thyroid hormone levels. We evaluated the effect of valproate and carbamazepine therapy on the thyroid hormone profile of epileptic children. Subjects included children aged 2-12 years receiving therapy for at least 6 months. Free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were(More)
The clinical and biochemical profile of dengue haemorrhagic fever (DHF) varies from epidemic to epidemic. We studied children hospitalized with DHF from September 2003 to December 2003. All were diagnosed, managed and monitored according to a standard protocol. Of the 34 who fulfilled the World Health Organization criteria of DHF, 22 (64.6%) were male. All(More)
Injuries are one of the leading causes of death and disability in Europe. Within Europe, death rates due to injuries are 60% higher in Eastern compared to Western Europe. This is especially due to unintentional injuries such as road traffic injuries, which is the 2nd leading cause of death in those 5-29 years. The cost of injuries is estimated at 1-2% of(More)
Reasons for the low coverage of immunization vary from logistic ones to those dependent on human behaviour. The study was planned to find out: (a) the immunization status of children admitted to a paediatric ward of tertiary-care hospital in Delhi, India and (b) reasons for partial immunization and non-immunization. Parents of 325 consecutively-admitted(More)
OBJECTIVE To evaluate immunogenicity and tolerability of single dose live attenuated injectable hepatitis A vaccine in four metropolitan cities of India. METHODS Live attenuated hepatitis A vaccine was administered to 505 children aged 18 to 60 months in four centers across India. Immunogenicity of the vaccine was assessed by estimation of anti-HAV(More)
OBJECTIVES To determine the efficacy of oral salbutamol for providing symptomatic relief in mild bronchiolitis. DESIGN Randomized double-blind placebo controlled trial. SETTING Pediatric Outpatient Department of a tertiary care hospital. SUBJECTS 140 infants (of 310 approached) with a clinical diagnosis of acute bronchiolitis with respiratory rate(More)