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Small G proteins in islet beta-cell function.

• Anjaneyulu Kowluru
• Endocrine reviews
• 2010

Glucose-stimulated insulin secretion from the islet beta-cell involves a sequence of metabolic events and an interplay between a wide range of signaling pathways leading to the generation of second… (More)

A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.

• Anjaneyulu Kowluru, Scott E Seavey, Christopher J Rhodes, Stewart A Metz
• The Biochemical journal
• 1996

Recently we described roles for heterotrimeric and low-molecular-mass GTP-binding proteins in insulin release from normal rat islets. During these studies, we observed that a protein with an apparent… (More)

Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells.

• Jingsong Li, Ruihua Luo, Anjaneyulu Kowluru, Guodong Li
• American journal of physiology. Endocrinology and…
• 2004

Stimulation of insulin secretion by glucose and other secretagogues from pancreatic islet beta-cells is mediated by multiple signaling pathways. Rac1 is a member of Rho family GTPases regulating… (More)

Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.

• Rajakrishnan Veluthakal, Suresh Vasu Madathilparambil, Phillip McDonald, Lawrence Karl Olson, Anjaneyulu Kowluru
• Biochemical pharmacology
• 2009

Using various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion (GSIS).… (More)

Identification and characterization of a novel protein histidine kinase in the islet beta cell: evidence for its regulation by mastoparan, an activator of G-proteins and insulin secretion.

• Anjaneyulu Kowluru
• Biochemical pharmacology
• 2002

Using insulin-secreting cells, we previously demonstrated that specific proteins associated with the cytosolic, secretory granule, and mitochondrial fractions undergo a novel type of phosphorylation… (More)

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets.

• B. D. Jayaram, Ismail Syed, Chandrashekara Nagaraj Kyathanahalli, Christopher J Rhodes, Anjaneyulu Kowluru
• Biochemical pharmacology
• 2011

Glucose-stimulated insulin secretion [GSIS] involves interplay between small G-proteins and their regulatory factors. Herein, we tested the hypothesis that Arf nucleotide binding site opener [ARNO],… (More)

Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: potential mechanisms and functional consequences.

• Anjaneyulu Kowluru, Andrea Matti
• Biochemical pharmacology
• 2012

The protein phosphatase 2A [PP2A] family of enzymes has been implicated in the regulation of a variety of cellular functions including hormone secretion, growth, survival and apoptosis. PP2A accounts… (More)

Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.

• Anjaneyulu Kowluru
• Biochemical pharmacology
• 2011

Glucose-stimulated insulin secretion [GSIS] involves a sequence of metabolic events leading to small G-protein [e.g., Rac1]-mediated cytoskeletal remodeling to promote granule mobilization toward the… (More)

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

• Ismail Syed, Chandrashekara Nagaraj Kyathanahalli, +4 authors Anjaneyulu Kowluru
• Diabetes
• 2011

OBJECTIVE To determine the subunit expression and functional activation of phagocyte-like NADPH oxidase (Nox), reactive oxygen species (ROS) generation and caspase-3 activation in the Zucker diabetic… (More)

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1.

• Wasanthi Subasinghe, Ismail Syed, Anjaneyulu Kowluru
• American journal of physiology. Regulatory…
• 2011

Reactive oxygen species (ROS) are important mediators of cellular signal transduction cascades such as proliferation, migration, and apoptosis. Chronic exposure of isolated β-cells to proinflammatory… (More)

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