Anjan K. Sinha

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Stent sizing and apposition have been shown to be important determinants of clinical outcome. This study evaluates the mechanical effects of undersizing and oversizing of stents on endothelial wall shear stress (WSS) and vessel wall stress to determine a possible biomechanical mechanism of in-stent restenosis and thrombosis. Three-dimensional computational(More)
Coronary flow reserve (CFR) is an important index of coronary microcirculatory function. The objective of this study was to validate the reproducibility and accuracy of intravascular conductance catheter-based method for measurements of baseline and hyperemic coronary flow velocity (and hence CFR). The absolute coronary blood velocity was determined by(More)
Photodynamic therapy (PDT) using 5-aminolaevulinic acid (ALA) to drive production of an intracellular photosensitiser, protoporphyrin IX (PpIX), is a promising cancer treatment. However, ALA-PDT is still suboptimal for thick or refractory tumours. Searching for new approaches, we tested a known inducer of cellular differentiation, methotrexate (MTX), in(More)
Photodynamic therapy using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) may be applied to the treatment of neoplasms in a variety of organs. In order to enhance existing regimens of photodynamic therapy, we investigated the effects of adding differentiation therapy to photodynamic therapy in human prostate cancer cells in vitro. The(More)
beta-D-Glucosidase, beta-D-glucosaminidase, acid phosphatase, and beta-D-galactosidase were monitored in the human foetal brain at different gestational periods. Glucosidase specific activity in all brain regions exhibits two peaks, at 8 g and 32 g foetal weights. Acid phosphatase exhibits very high specific activity in all brain regions at 5 g, but the(More)
729 were identical irrespective of whether ["C]-or [3H]-labetalol had been administered to the animals; therefore labetalol is not metabolized by N-dealkylation. The urine samples were concentrated on Amberlite XAD-2 resin, and the metabolites were purified by t.1.c. and paper chromatography. Enzymic hydrolysis, chemical analysis, t.l.c., paper(More)