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The purpose of this study was to elucidate the probable mechanism for the anti-arthritic activity of agnuside (AGN), a compound isolated from the leaf extract of Vitex negundo. The anti-inflammatory activity of AGN within a dose range of 1.56–12.50 mg/kg in normal and adrenalectomized rats was evaluated against different inflammagens. An array of(More)
The immunomodulatory activity of an Indian neutraceutical spice, saffron (Crocus sativus) was studied on Th(1) and Th(2) limbs of the immune system. Oral administration of alcoholic extract of Crocus sativus (ACS) at graded dose levels from 1.56-50 mg/kg p.o. potentiated the Th(2) response of humoral immunity causing the significant increases in(More)
This study was carried out to investigate the protective effect of Hydroxychavicol (HC), a phenolic compound derived from Piper betel on experimentally induced Alzheimer's disease (AD) in rat. HC at graded doses administered orally once daily for a duration of 21 days significantly improved the cognitive impairment and attenuated the elevated levels of(More)
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as(More)
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