Anjali Pandey

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Protease-Activated Receptor-1 (PAR1) is the prototypical member of a family of G protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the N-terminal exodomain of the receptor, which exposes a tethered peptide ligand that binds the receptor's heptahelical bundle to(More)
PAR1. A, Chemical structure of vorapaxar. B, Vorapaxar (VOR) decreases the maximal response of platelets to the PAR1 agonist peptide SFLLRN. Washed human platelets were preincubated with the indicated concentration of vorapaxar for 1h at 37 o C, and then SFLLRN was added at the final concentration indicated. After 15 minutes, activation of α 2b β 3 integrin(More)
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