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Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein1[OPEN]
The protease post-translationally fine-tunes a key enzyme in the synthesis of 5-Aminolevulinic acid during photoperiodic growth. 5-Aminolevulinic acid (ALA) is the first committed substrate ofExpand
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Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene editing by sequence-specificExpand
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Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
Targeted integration of a tumor-reactive T-cell receptor into the TRAC locus using CRISPR-Cas9 and AAV6 redirects primary human T cells against tumor cells in vitro and in vivo. Adoptive transfer ofExpand
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Two new species of Nephridiophaga (Zygomycota) in the Malpighian tubules of cockroaches
The Malpighian tubules of the cockroaches Archimandrita tessellata and Lucihormetica verrucosa were infected with stages of unicellular parasites. Plasmodial stages occurred freely in the lumen andExpand
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