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- Publications
- Influence
Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein1[OPEN]
- J. Apitz, Kenji Nishimura, +4 authors B. Grimm
- Biology, Medicine
- Plant Physiology
- 16 February 2016
The protease post-translationally fine-tunes a key enzyme in the synthesis of 5-Aminolevulinic acid during photoperiodic growth. 5-Aminolevulinic acid (ALA) is the first committed substrate of… Expand
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
- A. Moretti, L. Fonteyne, +41 authors C. Kupatt
- Medicine
- Nature Medicine
- 27 January 2020
Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene editing by sequence-specific… Expand
Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
- Julian Albers, T. Ammon, +12 authors A. Krackhardt
- Biology, Medicine
- Life Science Alliance
- 15 March 2019
Targeted integration of a tumor-reactive T-cell receptor into the TRAC locus using CRISPR-Cas9 and AAV6 redirects primary human T cells against tumor cells in vitro and in vivo. Adoptive transfer of… Expand
Two new species of Nephridiophaga (Zygomycota) in the Malpighian tubules of cockroaches
- R. Radek, Daniel Wellmanns, A. Wolf
- Biology, Medicine
- Parasitology Research
- 24 February 2011
The Malpighian tubules of the cockroaches Archimandrita tessellata and Lucihormetica verrucosa were infected with stages of unicellular parasites. Plasmodial stages occurred freely in the lumen and… Expand