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Recently, it was demonstrated that pancreatic new-born glucagon-producing cells can regenerate and convert into insulin-producing β-like cells through the ectopic expression of a single gene, Pax4. Here, combining conditional loss-of-function and lineage tracing approaches, we show that the selective inhibition of the Arx gene in α-cells is sufficient to(More)
BACKGROUND The a2 mating type locus gene lga2 is critical for uniparental mitochondrial DNA inheritance during sexual development of Ustilago maydis. Specifically, the absence of lga2 results in biparental inheritance, along with efficient transfer of intronic regions in the large subunit rRNA gene between parental molecules. However, the underlying role of(More)
The pancreas is an organ that can be subdivided into 2 functionally distinct compartments: (1) the exocrine tissue, composed of acinar and ductal cells, which are, respectively, implicated in the synthesis and transport of digestive enzymes and ions; (2) the endocrine tissue organized into cell clusters, termed islets of Langerhans. 1 Insulin acts to lower(More)
The recent discovery that genetically modified α cells can regenerate and convert into β-like cells in vivo holds great promise for diabetes research. However, to eventually translate these findings to human, it is crucial to discover compounds with similar activities. Herein, we report the identification of GABA as an inducer of α-to-β-like cell conversion(More)
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