Anja Nenninger

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Surprisingly little is known about the physical environment inside a prokaryotic cell. Knowledge of the rates at which proteins and other cell components can diffuse is crucial for the understanding of a cell as a physical system. There have been numerous measurements of diffusion coefficients in eukaryotic cells by using fluorescence recovery after(More)
Diffusion in the bacterial cytoplasm is regarded as the primary method of intracellular protein movement and must play a major role in controlling the rates of cell processes. A number of recent studies have used green fluorescent protein (GFP) tagging and fluorescence microscopy to probe the movement and distribution of proteins in the bacterial cytoplasm.(More)
Baeomycesic acid (1), a β-orcinol depside isolated from the lichen Thamnolia subuliformis (Ehrh.) W. Culb. was tested for in vitro inhibitory effects on arachidonate metabolism. Results showed that baeomycesic acid has potent dose-dependent inhibitory effects on 5-lipoxygenase isolated from porcine leucocytes, with an IC(50) value of 8.3 μM.(More)
YidC/OxaI play essential roles in the insertion of a wide range of membrane proteins in Eschericha coli and mitochondria, respectively. In contrast, the chloroplast thylakoid homolog Albino3 (Alb3) facilitates the insertion of only a specialized subset of proteins, and the vast majority insert into thylakoids by a pathway that is so far unique to(More)
Heterocyst-forming filamentous cyanobacteria are true multicellular prokaryotes, in which heterocysts and vegetative cells have complementary metabolism and are mutually dependent. The mechanism for metabolite exchange between cells has remained unclear. To gain insight into the mechanism and kinetics of metabolite exchange, we introduced calcein, a 623-Da(More)
Macfadyena unguis-cati (L.) has been widely used in folk medicine as an anti-inflammatory, antimalarial and antivenereal. The purpose of this study was to chemically characterize the main plant components, and to evaluate the biological properties of some of the fractions derived from leaves (MACb) and liana (MACa) of this plant. Chemical characterization(More)
BACKGROUND In cyanobacteria the photosystems are localised to, and maintained in, specialist membranes called the thylakoids. The mechanism driving the biogenesis of the thylakoid membranes is still an open question, with only two potential biogenesis factors, Vipp1 and Alb3 currently identified. METHODOLOGY/PRINCIPAL FINDINGS We generated a slr1768(More)
Marchantins and related compounds, isolated from different species of liverworts, were investigated for their inhibitory potential on cyclooxygenase (COX) and 5-lipoxygenase 5-(LOX), the key enzymes of the arachidonic acid cascade, and additionally in a cell-free lipid-peroxidation system. The results were compared with rate constants obtained in(More)
Ferritin-like proteins constitute a remarkably heterogeneous protein family, including ferritins, bacterioferritins and Dps proteins. The genome of the filamentous heterocyst-forming cyanobacterium Nostoc punctiforme encodes five ferritin-like proteins. In the present paper, we report a multidimensional characterization of these proteins. Our phylogenetic(More)
The presence of an alkamide in lichens is reported for the first time. The alkamide was isolated from Stereocaulon alpinum Laur. and identified through spectroscopic analysis as 9-cis-octa-decenamide (1). With reference to previously known activity of alkamides from both the plant and animal kingdoms on inflammatory processes, 1 was tested for in vitro(More)