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BACKGROUND While human immunodeficiency virus (HIV)-related causes of death have been well documented in developed countries, in Africa data are scanty and mainly based on autopsy studies from city hospitals which are highly selective and may not represent causes of HIV-associated deaths in the general population. This study, from a rural population,(More)
OBJECTIVE To investigate the role of HIV-1 envelope subtypes on disease progression in a rural cohort of Ugandan adults where two major HIV-1 subtypes (A and D) exist. METHODS Participants of a clinical cohort seen between December 1995 and December 1998 had blood collected for HIV-1 subtyping. These included prevalent cases (people already infected with(More)
BACKGROUND HIV-1 infection is associated with lower fertility among women in sub-Saharan Africa and this association is not explained by the frequency of sexual intercourse, illness, knowledge of HIV status or infection with other sexually transmitted diseases. Women with fertility problems are at increased risk of marital instability and, therefore, HIV(More)
OBJECTIVE To determine the prevalence of mucocutaneous conditions and their association with HIV-1 infection in a rural community in Uganda. METHODS In a prospective cohort study, participants were recruited from a large population study and invited to attend a clinic every 3 months for a detailed medical interview and a thorough physical examination. All(More)
1. A study was made of the effects of mental arithmetic, and of listening to prose, on the bradycardia produced by breath holding with and without immersion of the face in cold water. 2. Bradycardia was produced in both air and water, but the response was significantly greater on face immersion. The reaction was attenuated by mental arithmetic in both air(More)
Psychophysiologic reactions to behavioral challenges were examined in men aged 55 or less with no prior history of cardiovascular disorder. Three age-matched groups of twelve were recruited through factory screening: mild hypertensives (blood pressure in the range 175/105-145/90 persisting on retest), transient hypertensives (blood pressure above criterion(More)
The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after antimalarial drug treatment. However, none of the previous reports has clearly assessed the change of genetic diversity following drug treatment. In the(More)
OBJECTIVES To describe the early manifestations of HIV-1 infection before the development of AIDS, in a rural Ugandan population. METHODS Three monthly follow-up of HIV-1-infected and uninfected participants in an HIV-1 natural history cohort from the start of the cohort in 1990 to the end of 1996. RESULTS A total of 107 persons with prevalent infection(More)