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Receptor tyrosine kinases (RTKs) are cell-surface molecules that transduce signals for cell growth and differentiation. The RTK encoded by the c-ret proto-oncogene is rearranged and constitutively activated in a large proportion of thyroid papillary carcinomas, and germ-line point mutations in c-ret seem to be responsible for the dominantly inherited cancer(More)
c-ret encodes a tyrosine kinase receptor that is necessary for normal development of the mammalian enteric nervous system. Germline mutations in c-ret lead to congenital megacolon in humans, while a loss-of-function allele (ret.k-) causes intestinal aganglionosis in mice. Here we examine in detail the function of c-ret during neurogenesis, as well as the(More)
The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system. Newborn mice homozygous for a mutation in c-ret displayed renal agenesis or severe hypodysplasia, suggesting a critical role for this gene in metanephric kidney development. To investigate the embryological basis of(More)
During spinal cord development, commissural (C) neurons, located near the dorsal midline, send axons ventrally and across the floor plate (FP). The trajectory of these axons toward the FP is guided in part by netrins. The mechanisms that guide the early phase of C axon extension, however, have not been resolved. We show that the roof plate (RP) expresses a(More)
Amid calls for integrating science, technology, engineering, and mathematics (iSTEM) in K–12 education, there is a pressing need to uncover productive methods of integration. Prior research has shown that increasing contextual linkages between science and mathematics is associated with student problem solving and conceptual understanding. However, few(More)
A case study comparison of student performance shows that 9 th grade students who have completed one year of instruction in modeling-based physics scored significantly higher on scientific reasoning and mathematical skills test when compared to 9 th grade students who have completed one year of instruction in inquiry-based biology. Proposal Summary A case(More)
In the fall of 2011 fi ve secondary level biology teachers in the northeast United States implemented an experimental instructional module that challenged their students with a design problem. This challenge required students to perform both mathematical analysis and the engineering application of biological concepts in order to reach a resolution. Specifi(More)
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