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We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae.(More)
The recently sequenced genome of the filamentous fungus Ashbya gossypii revealed remarkable similarities to that of the budding yeast Saccharomyces cerevisiae both at the level of homology and synteny (conservation of gene order). Thus, it became possible to reinvestigate the S. cerevisiae genome in the syntenic regions leading to an improved annotation. We(More)
UNLABELLED QuasR is a package for the integrated analysis of high-throughput sequencing data in R, covering all steps from read preprocessing, alignment and quality control to quantification. QuasR supports different experiment types (including RNA-seq, ChIP-seq and Bis-seq) and analysis variants (e.g. paired-end, stranded, spliced and allele-specific), and(More)
Reconstructing a person’s face from its skeletal remains is a task that has over many decades fascinated artist and scientist alike. In this paper we treat facial reconstruction as a machine learning problem. We use separate statistical shape models to represent the skull and face morphology. We learn the relationship between the parameters of the models by(More)
For the most part metazoan genomes are highly methylated and harbor only small regions with low or absent methylation. In contrast, partially methylated domains (PMDs), recently discovered in a variety of cell lines and tissues, do not fit this paradigm as they show partial methylation for large portions (20%-40%) of the genome. While in PMDs methylation(More)
We present a model-based approach for segmentation of the skull from T1 weighted MR images of the human head. Segmentation is performed by fitting a statistical shape model of the skull into a crudely pre-segmented version of the image. This yields a segmentation result that is constrained to the normal skull anatomy and thus gives a statistically(More)
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