Anita Jasper

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In the West model of zonal distribution of pulmonary blood flow, increases in flow down zone 2 are attributed to an increase in driving pressure and a decrease in resistance resulting from recruitment and distension. The increase in flow down zone 3 is attributed to a decrease in resistance only. Recent studies indicate that, besides the pressure required(More)
Dependency of oxygen consumption (VO2) on oxygen delivery (DO2) in patients with adult respiratory distress syndrome and with congestive heart failure has been reported previously. We evaluated this relationship in 11 patients with pulmonary hypertension, 8 with primary pulmonary hypertension (PPH), and 3 with pulmonary hypertension secondary to chronic(More)
We previously have shown that in patients with adult respiratory distress syndrome (ARDS) oxygen consumption (VO2) is linearly related to oxygen delivery (DO2) below a threshold DO2 of 21 ml/min/kg. To evaluate this relationship in chronic congestive heart failure (CHF), we studied eight patients with chronic CHF at baseline and during treatment with(More)
We compared two modes of aerosol bronchodilator delivery in 34 patients hospitalized with obstructive airways diseases. The standard mode, therapist-administered up-draft nebulization (UDN), is labor-intensive and therefore relatively costly. The alternative mode, self-administration by a metered dose inhaler (MDI), is less costly, but its efficacy over an(More)
We performed YAG laser photoresection in 11 patients with tracheal or mainstem bronchial obstruction due to malignant or benign disorders. We used maximal inspiratory-expiratory flow-volume loops and expiratory volume-time plots to assess air flow limitation. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow(More)
Pulmonary vasodilators are variably efficacious in primary pulmonary hypertension (PPH). None has consistently improved hemodynamics enough to obviate the need for complex and potentially hazardous testing of several vasodilators. Prostaglandin E1 (PGE1), a potent, short-acting pulmonary vasodilator, was administered to seven patients with PPH in order to(More)
We studied the relationship between the pulmonary artery wedge pressure (Pw) and pulmonary venous pressure (Ppv) at 2 alveolar pressures (PA) in 7 isolated perfused dog lobes. If PA were the critical pressure in the pulmonary circulation, one would expect Pw to equal Ppv for all Ppv greater than PA. Relative to the hilum, the average critical pressure in(More)
In 8 anesthetized dogs, during isocapnic hyperoxia we studied the effect of assisted ventilation (AV) on ventilatory drive, inspiratory off-switch volume (Voff) and duration of inspiratory diaphragmatic activity (Tdi). Tidal volumes (Vt) during AV were double spontaneous Vt. Two electrodes were inserted in the diaphragm to obtain the electromyogram (EMG).(More)
Granulocytic sarcoma occurs most commonly in acute myelogenous leukemia. The appearance of granulocytic sarcoma in chronic myelogenous leukemia signals accelerated phase/ blast transformation. This is a rare case of undiagnosed chronic myelogenous leukemia with granulocytic sarcoma causing cord compression, which went into tumour lysis syndrome requiring(More)
In eight isolated dog lobes, we examined the change in extra-alveolar perimicrovascular hydrostatic pressure (Pis) due to lung inflation. The vasculature was filled with autologous plasma. Pulmonary arterial and venous lines were connected to a common plasma reservoir. Perimicrovascular volume change (delta Vis), compliance (Cis), and the microvascular(More)