Anita Curley

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Behavioural pharmacology relies on animal models which are primarily validated using the male laboratory rat. Many researchers solely employ male animals in studies; this is primarily due to concerns about the impact of variations in the female estrous cycle on behavioural responses. The objective of the present study therefore was to examine whether sex(More)
OBJECTIVE To describe patterns of clinical bleeding in neonates with severe thrombocytopenia (ST and platelet count <60 × 10(9) L(-1)), and to investigate the factors related to bleeding. STUDY DESIGN Seven tertiary-level neonatal units enrolled neonates (n = 169) with ST. Data were collected prospectively on all clinically apparent haemorrhages.(More)
Purpose To investigate whether current UK retinopathy of prematurity (ROP) screening guidelines miss the early development of pre-threshold type 1 ROP in some neonates born small for gestational age (SGA) and consider if the guidelines should be changed.Methods Data were collected on neonates of ⩽31 completed weeks gestation and/or birth weight (BW) ⩽1500 g(More)
Feeding of 260 ppm of leptophos to mallard ducklings caused delayed neurotoxicity similar to that reported for hens. Thus leptophos caused ataxia, with subsequent paralysis, loss of appetite, and slow-down in the growth rate of the treated birds. Spinal lesions were identical in morphology and distribution to those seen in hens following leptophos(More)
Hexachlorophene (HCP), a chlorinated phenolic hydrocarbon with bacteriostatic properties against Staphylococcus, is used in a number of topical products. Absorption through normal and damaged human skin has been appreciated and neurologic changes have been described in experimental animals, but instances of human toxicity have been reported infrequently. A(More)
Background: Infants admitted to neonatal intensive care are at high risk of bleeding. Our objective was to develop and pilot a bleeding assessment tool (BAT) and validate its use in neonates admitted to intensive careMethods: The BAT was developed, reviewed and modified from the WHO bleeding score by a team of neonatologists, haematologists and(More)
Background and aim: Insertion of percutaneous central venous lines (PCVLs) is an everyday procedure in the neonatal unit. The presence of PCVL is an important risk factor for catheter-related sepsis. We aimed to study the characteristics of infants with indwelling PCVLs who develop catheter-associated sepsis (CAS).Design and Methods: Prospective study in(More)
Neonatal thrombocytopenia and bleeding are common and important clinical problems in neonatology affecting 25% of all neonatal unit admissions. Platelet transfusions are frequently used in modern neonatal clinical practice as prophylaxis in thrombocytopenic neonates. Policies and protocols for neonatal platelet transfusion therapy vary widely between(More)
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