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The neuroprotective effect of tropisetron on vincristine-induced neurotoxicity.
TLDR
Investigation of a suppressive effect of tropisetron on VCR-induced neuropathy and whether this effect exerts through the 5-HT3 receptor or not demonstrates that tropisets could be a neuroprotective agent for prevention of V CR- induced neuropathy via a receptor-independent pathway. Expand
Tropisetron ameliorates early diabetic nephropathy in streptozotocin‐induced diabetic rats
TLDR
The present study suggests that tropisetron may be a protective agent in early diabetic nephropathy, and its action is mediated, at least in part, by anti‐oxidative and anti‐inflammatory mechanisms that appear to be independent of the 5‐HT3 receptor. Expand
Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy.
TLDR
Results showed that tropisetron could ameliorate kidney injury in the early stage of diabetic nephropathy in rats, and can be attributed, at least in part, to the suppression of diabetes-induced increases in calcineurin expression in kidney tissue. Expand
Ipsilateral common iliac artery plus femoral artery clamping for inducing sciatic nerve ischemia/reperfusion injury in rats: a reliable and simple method
TLDR
The authors' observations led to an easy-to-use but strong enough method for inducing and studying I/R injury in peripheral nerves, and Axonal swelling and IFD were found to happen only after 4 and 7 days, respectively. Expand
Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity
TLDR
SMA-tDodSNO can be used as a successful strategy to increase the efficacy of Dox and SMA-Dox in a model of triple-negative breast cancer, without causing significant toxicity as monitored through body weight loss. Expand
Pretreatment of CAV Combination Chemotherapy with Tropisetron Shows Less Cardio and Neurotoxicity Side Effects in Rats
TLDR
It is suggested that tropisetron is beneficial for the prevention of cardiotoxicity and neurotoxicity and could be considered as a new indication for alleviation of side effects of these drugs in combination therapies. Expand
Tropisetron ameliorates ischemic brain injury in an embolic model of stroke
TLDR
Tropisetron attenuates brain damage after a thromboembolic event in rats and improves behavioral scores, diminished elevated tissue MPO activity, and reduced TNF-α levels compared to control group. Expand
The Cardioprotective Effects of an Antiemetic Drug, Tropisetron, on Cardiomyopathy Related to Doxorubicin
TLDR
It is demonstrated that tropisetron has potent cardioprotective effects against DOX-induced cardiotoxicity in rats and robustly counteracted the increase in the levels of serum biomarkers and alleviated the histopathological changes in rats’ hearts as compared with the DOX group. Expand
Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability
TLDR
The NP was markedly superior as a photoactive NO donor in comparison to the S‐nitrosothiols GSNO and SNAP, which are commonly used in experimental studies, as well as sodium nitroprusside, a clinically used vasodilator. Expand
Data characterizing the biophysical and nitric oxide release properties of the tDodSNO – Styrene maleic anhydride nanoparticle SMA-tDodSNO
TLDR
Data is presented describing the synthesis and characterisation of a novel NO releasing nanoparticle formed by encapsulation of the NO donor tDodSNO into a co-polymer of styrene and maleic acid (SMA) to afford SMA-tDod SNO. Expand
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