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Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine
AbstractObjectiveTo study the influence of CYP3A4 inhibition by ketoconazole on the disposition of venlafaxine in individuals with different CYP2D6 pheno- and genotypes.MethodsIn an open two-phaseExpand
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The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment.
AIMS The effect of the CYP3A4 inhibitors ketoconazole and diltiazem on the pharmacokinetics of oestrone was studied in six healthy postmenopausal women after treatment with a single oral dose ofExpand