The aim of this study was to evaluate the impact of polymorphisms in the EPHX1 (c.416A > G, c.337T > C) and CYP3A4*22 genes involved in carbamazepine (CBZ) metabolism and pharmacoresistance among 118 Tunisian patients with epilepsy under maintenance dose of CBZ. These genetic polymorphisms were analyzed by PCR-RFLP. Associations between plasma CBZ… (More)
maladie de Hirayama dans cette série tunisienne sont comparables à ceux rapportés dans la littérature en dehors d'une atteinte strictement féminine. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Glutathione-S-transferases enzymes are involved in the detoxification of several endogenous and exogenous substances. These genetic pathways could be involved in the therapeutic efficacy and toxic effects of carbamazepine by modulating metabolic profiles. In this present study, we evaluated the effects of two glutathione-S-transferase polymorphisms, GSTM1… (More)