Learn More
The development of cancer is a multistep process involving mutations in proto-oncogenes, tumor suppressor genes, and other genes which control cell proliferation, telomere stability, angiogenesis, and other complex traits. Despite this complexity, the cellular pathways controlled by the p53 tumor suppressor protein are compromised in most, if not all,(More)
The antigen presentation to lymphocytes in brain occurs in two steps. Initially it happens at perivascular spaces by perivascular microglia/macrophage population and finally at the site of inflammation deep into brain parenchyma by the resident microglia. But recent evidence challanges the existing notion of involvement of distinct and different cells at(More)
(I) We exhibit a set of 23 points in the plane that has dilation at least 1.4308, improving the previous best lower bound of 1.4161 for the worst-case dilation of plane spanners. (II) For every n ≥ 13, there exists an n-element point set S such that the degree 3 dilation of S equals 1 + √ 3 = 2.7321. .. in the domain of plane geometric spanners. In the same(More)
In recent years most of the cloud computing community adopt an infrastructure centric approach to optimize the cost of cloud resources considering both Cloud Computing Service Users(CCSU) and Cloud Computing Service Providers(CCSP). In this paper we have brought up the concept of Application-centric Cloud. With Application-centric Cloud we propose an(More)
To characterize genetic contributions toward aberrant splicing of the hyaluronan synthase 1 (HAS1) gene in multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), we sequenced 3616 bp in HAS1 exons and introns involved in aberrant splicing, from 17 patients. We identified a total of 197 HAS1 genetic variations (GVs), a range of 3 to 24 GVs/patient,(More)
A grid is described as a distributed network which comprises of heterogeneous and non-dedicated elements. The heterogeneity of a grid is not only defined in terms of computing elements and operating systems but also in terms of implementation of policies, policy decisions and the environment. In this paper we have described in detail the architecture of the(More)
Let δ 0 (P, k) denote the degree k dilation of a point set P in the domain of plane geometric spanners. If Λ is the infinite square lattice, it is shown that 1+ √ 2 ≤ δ 0 (Λ, 3) ≤ (3+2 √ 2) 5 −1/2 = 2.6065. .. and δ 0 (Λ, 4) = √ 2. If Λ is the infinite hexagonal lattice, it is shown that δ 0 (Λ, 3) = 1 + √ 3 and δ 0 (Λ, 4) = 2. All our constructions are(More)
The long perceived notion that G-Protein Coupled Receptors (GPCRs) function in monomeric form has recently been changed by the description of a number of GPCRs that are found in oligomeric states. The mechanism of GPCR oligomerization, and its effect on receptor function, is not well understood. In the present study, coarse grained molecular dynamics (CGMD)(More)