Anirban Ghosh

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Squalene synthase (SS) represents a putative branch point in the isoprenoid biosynthetic pathway capable of diverting carbon flow specifically to the biosynthesis of sterols and, hence, is considered a potential regulatory point for sterol metabolism. For example, when plant cells grown in suspension culture are challenged with fungal elicitors, suppression(More)
Suppose that a fence needs to be protected (perpetually) by k mobile agents with maximum speeds v1, . . . , vk so that no point on the fence is left unattended for more than a given amount of time. The problem is to determine if this requirement can be met, and if so, to design a suitable patrolling schedule for the agents. Alternatively, one would like to(More)
The long perceived notion that G-Protein Coupled Receptors (GPCRs) function in monomeric form has recently been changed by the description of a number of GPCRs that are found in oligomeric states. The mechanism of GPCR oligomerization, and its effect on receptor function, is not well understood. In the present study, coarse grained molecular dynamics (CGMD)(More)
A grid is described as a distributed network which comprises of heterogeneous and non-dedicated elements. The heterogeneity of a grid is not only defined in terms of computing elements and operating systems but also in terms of implementation of policies, policy decisions and the environment. In this paper we have described in detail the architecture of the(More)
Capsicum annuum (L.) expresses diverse potato type II family proteinase inhibitors comprising of inhibitory repeat domain (IRD) as basic functional unit. Most IRDs contain eight conserved cysteines forming four disulfide bonds, which are indispensible for their stability and activity. We investigated the functional significance of evolutionary variations in(More)
In their recent study, Abe et al. [1] discuss the cellular elongation or filamentation phenomenon observed in a fraction of an Escherichia coli K12 (strain BW25113) population exposed to a sublethal high hydrostatic pressure (HP) shock (75 MPa, 30 min, 37 C). More specifically, they attribute this filamentation to direct HP effects on FtsZ polymerization(More)
I) We exhibit a set of 23 points in the plane that has dilation at least 1.4308, improving the previous best lower bound of 1.4161 for the worst-case dilation of plane spanners. (II) For every n ≥ 13, there exists an n-element point set S such that the degree 3 dilation of S equals 1 + √ 3 = 2.7321 . . . in the domain of plane geometric spanners. In the(More)
In this study, we examined the intracellular whereabouts of Mrr, a cryptic type IV restriction endonuclease of Escherichia coli K12, in response to different conditions. In absence of stimuli triggering its activity, Mrr was found to be strongly associated with the nucleoid as a number of discrete foci, suggesting the presence of Mrr hotspots on the(More)
Human ocular albinism type 1 protein (OA1)-a member of the G-protein coupled receptor (GPCR) superfamily-is an integral membrane glycoprotein expressed exclusively by intracellular organelles known as melanocytes, and is responsible for the proper biogenesis of melanosomes. Mutations in the Oa1 gene are responsible for the disease ocular albinism. Despite(More)