Anirban C. Mitra

Learn More
Throat swabs of 34 of 328 family contacts of 52 smallpox cases, examined 4-8 days after the onset of the disease in the family, were positive for variola virus. The log titre of virus per swab ranged from 2 to 3.95. A higher proportion of unvaccinated than of vaccinated contacts excreted the virus. Only 4 of the virus-positive contacts developed clinical(More)
Excretion of virus in the throat, urine, and conjunctiva of smallpox patients was studied daily for 2-3 weeks after the onset of fever. The virus titre in the throat and urine of haemorrhagic and confluent cases was higher than in discrete cases. The duration of virus excretion was also greater in confluent cases than in discrete cases. Conjunctival swabs(More)
The toxicological structure-activity relationships are investigated using conceptual DFT based descriptors like global and local electrophilicities. In the present work the usefulness of electrophilicity in predicting toxicity of several polyaromatic hydrocarbons (PAH) is assessed. The toxicity is expressed through biological activity data (pIC50) defined(More)
Log titres of smallpoxvirus (pock-forming units per 0.1 g of scab) were estimated in scabs from 5 patients from the 13th to the 24th days of illness. They were found to vary from 3.72 to 6.54 with no diminution as convalescence progressed, and they were not related to the primary vaccination status of the patient or the clinical severity of the disease.
Blood samples from 57 contacts of 6 smallpox cases were tested for haemagglutination-inhibiting (HI) and neutralizing antibodies. All 6 contacts who subsequently developed smallpox were unvaccinated and had neutralizing antibody titres of 10 or less. However, 6 unvaccinated contacts with similar antibody levels did not develop smallpox. None of the 41(More)
The reliable detection, sizing, and sorting of viruses and nanoparticles is important for biosensing, environmental monitoring, and quality control. Here we introduce an optical detection scheme for the real-time and label-free detection and recognition of single viruses and larger proteins. The method makes use of nanofluidic channels in combination with(More)
The pattern of intrafamilial transmission of smallpox in Calcutta was studied in 43 index cases, 3 of which were haemorrhagic, 14 confluent, and 26 discrete. They had 741 contacts. The attack rate in vaccinated contacts was significantly less than in unvaccinated contacts, but there was no such difference in the case rates caused by severe and mild index(More)