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Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg(-1)) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg(-1)) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated(More)
Stomach ulceration is a major side effect of most chemopreventive drugs. We have established that although resveratrol is a promising chemopreventive compound, it delays the ulcer healing process. However, its analog hydroxystilbene-1 (HST-1) was devoid of such an ulcerogenic side effect. Consequently, here we tried to explore the chemopreventive efficacy(More)
We have previously demonstrated that resveratrol (Resv)-induced cellular apoptosis occurs after formation of reactive oxygen species (ROS) but the role of GSH has not been well defined. Our experimental data enumerated that Resv treatment (50 μm) induced apoptosis in human leukemic monocyte lymphoma cells, which was preceded by cellular GSH efflux. High(More)
Exposure of stationary phase cells of Saccharomyces cerevisiae to 10 mM HCl (pH approximately 2) resulted in cell death as a function of time (up to 6 h) with most (about 40%-65%) of the cells showing apoptotic features including chromatin condensation along the nuclear envelope, exposure of phosphatidylserine on the outer leaflet of cytoplasmic membrane,(More)
Despite its potential, use of trans-resveratrol as an anticancer drug is severely constrained because of its tendency to prolong gastric ulceration. We found that in addition to delaying ulcer healing, trans-resveratrol also aggravated acute gastric ulceration induced by the nonsteroidal anti-inflammatory drugs by reducing the synthesis of prostaglandin(More)
This paper 1 gives a brief description on the methods adopted for the task of author-profiling as part of the competition PAN 2016 [1]. Author profiling is the task of predicting the author's age and gender from his/her writing. In this paper, we follow a two-level ensemble approach to tackle the cross-genre author profiling task where training documents(More)
S-adenosyl-L-methionine (AdoMet, 1mM) protects the stationary phase cells of Saccharomyces cerevisiae against the killing effect of acid (10mM HCl, pH approximately 2). Both the acid and the acid plus AdoMet treatment for 2h increased the plasma membrane H(+)-ATPase activity; thereafter it decreased to the basal level. AdoMet partially recovered the(More)
Affiliations: Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic medical Sciences & I.P.G.M.E.&R, 244B, Acharya Jagadish Chandra Bose Road, Kolkata700020, India (P. G., A. D. and S. K. B.), Department of Pharmacology, Dr. B.C. Roy Post Graduate Institute of Basic medical Sciences & I.P.G.M.E.&R, Kolkata-700 020 (R. S. and M. C.),(More)
We show that when the antisymmetric Kalb-Ramond field is included in the Randall-Sundrum scenario, although the hierarchy problem can be solved, it requires an extreme fine tuning of the Kalb-Ramond field (about 1 part in 10 62). We interpret this as the return of the problem in disguise. Further, we show that the Kalb-Ramond field induces a small negative(More)