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Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta.

• Anindita Das, Lei Xi, Rakesh C. Kukreja
• The Journal of biological chemistry
• 2008

Sildenafil, a potent inhibitor of phosphodiesterase-5 (PDE-5) induces powerful protection against myocardial ischemia-reperfusion injury. PDE-5 inhibition increases cGMP levels that activate… (More)

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes

• Mariano J. Scian, Katherine E Roth Stagliano, +6 authors Sumitra Deb
• Oncogene
• 2004

We have studied the mechanism of mutant p53-mediated oncogenesis using several tumor-derived mutants. Using a colony formation assay, we found that the majority of the mutants increased the number of… (More)

Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

• Tasneem Motiwala, Kalpana Ghoshal, +7 authors Christoph Plass
• Oncogene
• 2003

A diet lacking folic acid and choline and low in methionine (folate/methyl deficient diet, FMD diet) fed to rats is known to produce preneoplastic nodules (PNNs) after 36 weeks and hepatocellular… (More)

EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells

• Marianna Zagurovskaya, Mohammed Momin Shareef, +7 authors Md. Mobasher Ahmed
• Oncogene
• 2009

In this study, we investigated the functional role of early growth response-1 (Egr1 gene) in the regulation of radiation-induced clonogenic inhibition and apoptosis in p53 wild-type and mutant… (More)

Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis.

• Anindita Das, Damodaran Chendil, +4 authors Maiada Mohamed Yousif Ahmed
• The Journal of biological chemistry
• 2001

In this study, we sought to investigate the mechanism of the proapoptotic function of Egr-1 in relation to p53 status in normal isogenic cell backgrounds by using primary MEF cells established from… (More)

Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2.

• Maiada Mohamed Yousif Ahmed, Rachael A Alcock, +7 authors James W. Freeman
• The Journal of biological chemistry
• 2002

In this study, we investigated whether lack of transforming growth factor beta (TGF-beta) type II receptor (RII) expression and loss of TGF-beta signaling played a role in radiation resistance of… (More)

Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3.

• Damodaran Chendil, Anindita Das, Swatee Dey, Mohammed Riyaz Mohiuddin, Maiada Mohamed Yousif Ahmed
• Cancer biology & therapy
• 2002

Ionizing radiation caused induction NF kappa B activity and Bcl-2 protein expression in the radioresistant p53 null human prostate cancer cell line, PC-3. Exposure of PC-3 cells to Ad5-I kappa B… (More)

Abstract 4829: Dietary Supplementation of Nitrate Protects Against Doxorubicin-Induced Ventricular Dysfunction and Cardiomyocyte Cell Death in Mice

• Shu-Guang Zhu, Anindita Das, Lei Xi, Rakesh C. Kukreja
• 2008

Expression of NF-kappaB in epidermis and the relationship between NF-kappaB activation and inhibition of keratinocyte growth.

• Joe Takao, Tatsuo Yudate, +4 authors Ponciano D. Cruz
• The British journal of dermatology
• 2003

BACKGROUND Nuclear factor-kappaB (NF-kappaB) is a transcription factor involved in a number of signalling pathways in many cell types. NF-kappaB in mice has been implicated as an important regulator… (More)

Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.

• Makoto Bonkobara, Anindita Das, Joe Takao, Ponciano D. Cruz, Kiyoshi Ariizumi
• The British journal of dermatology
• 2003

BACKGROUND Both intercellular and intracellular signals are transduced primarily by interactions of secreted and/or membrane-anchored polypeptides, and they play a pivotal role in regulating… (More)

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