Animesh Agrawal

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A method has been developed to induce and retain a contractile phenotype for vascular smooth muscle cells, as the first step towards the development of a biomimetic blood vessel construct with minimal compliance mismatch. Melt spun PCL fibers were deposited on a mandrel to form aligned fibers of 10 μm in diameter. The fibers were bonded into aligned(More)
Optimum conditions for beta-galactosidase production by K. fragilis were studied. Enzyme production has a maximum after 8-12 h of incubation. Composition of whey (from different sources) did not affect enzyme production. Different heart treatments also had no effect. Whey reconstituted to 8-12% total solids and adjusted to pH 4.0 afforded maximum enzyme(More)
In biological hydrogels, the gel matrix is usually reinforced with micro- or nanofibers, and the resulting composite is tough and strong. In contrast, synthetic hydrogels are weak and brittle, although they are highly elastic. The are many potential applications for strong synthetic hydrogels in medical devices, including as scaffolds for tissue growth.(More)
Considerable interest has arisen in precision fabrication of cell bearing scaffolds and structures by free form fabrication. Gelatin is an ideal material for creating cell entrapping constructs, yet its application in free form fabrication remains challenging. We demonstrate the use of gelatin, crosslinked with microbial transglutaminase (mTgase), as a(More)
UNLABELLED The optimal bio-artificial blood vessel construct is one that has a compliant tubular core with circumferentially aligned smooth muscle cells (SMCs). Obtaining this well-aligned pattern of SMCs on a scaffold is highly beneficial as this cellular orientation preserves the SMC contractile phenotype. We used 3D patterning to create channels on a(More)
The particular smart textiles effort here is aimed at stress and strain sensors printed on textiles to be the equivalent of proprioception in biology, providing information about the actions of the body for the purposes of controlling and monitoring muscle action. We envisage printing arrays of simple piezoresistive sensors onto fabrics and using these to(More)
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