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Marked suppression of IgM, IgG and IgA plaque forming cells was observed in mice immunized with sheep erythocytes (T-dependent antigen) during acute Plasmodium berghei infection whereas during chronic infection mild immunosuppression was observed. When mice were immunized with polyvinylpyrrolidone (T-independent antigen), suppression in the number of plaque(More)
The adherence of Entamoeba histolytica trophozoites to target cells was studied using a monoclonal antibody to a major surface antigen of 66 kD. Preincubation of trophozoites with monoclonal antibody decreased their ability to adhere to and engulf erythrocytes and to destroy Chinese hamster ovary cells. The monoclonal antibody was specific for the 66 kD(More)
Lymphocytotoxic antibodies (LCAs) were assayed in serum samples from 60 patients of leprosy spectrum before starting multi-drug therapy (MDT). Seventeen healthy volunteers without any history of viral infection provided control samples. Post treatment follow up samples were also included in the study. In all pretreatment sera of LL, BL and BT/TT patients(More)
A comparative study of specific and non-specific immunosuppression has been carried out in acute and chronic Plasmodium berghei infected mice in an in vivo system. In our previous studies, immunosuppression during acute P. berghei infection was attributed to T lymphocytes when we studied modulation of blastogenic response of lymphocytes in an in vitro(More)
The role of lymphocytotoxic antibodies in elimination of lymphocytes and characterization of these antibodies during Plasmodium berghei infection was examined in BALB/c mice. When assayed at 15 degrees, an increase in lymphocytotoxic levels above base line values was detected in acute infection when parasitaemia exceeded 10%. There was an increase in(More)
The role of mebendazole in treatment of hydatid disease was investigated in a mouse model of human Echinococcus granulosus infection. Each animal received 2000 protoscoleces by intraperitoneal injection. Mebendazole, 50 mg/kg or 200 mg/kg body weight daily for 21 d, was given to 3 groups of animals 2, 4 and 6 months after infection. Significant decreases in(More)