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Progress towards a vaccine against malaria is advancing rapidly with several candidate antigens being tested for their safety and efficacy. In present investigation, two polypeptides (43 and 48 kDa) of Plasmodium berghei (NK-65) were identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Immunogenicity and protective efficacy of both these(More)
BACKGROUND Renal epithelial cell injury by reactive oxygen species is pre-requisite step in the pathogenesis of urolithiasis. Rutin and curcumin are polyphenolic compounds known to have antioxidant and anti-inflammatory activities, but their effect on urolithiasis is yet to be elucidated. In the present study, we have investigated the inhibitory effect of(More)
Incorporation of the parasite's subcellular fractions in subunit vaccines can be a possible approach for formulation of vaccine against malaria. In this study, the immunogenicity and protective efficacy of 10,000g fraction of blood stage Plasmodium berghei was evaluated in mouse model. This fraction induced higher levels of anti-parasite antibodies and(More)
The hand has drawn great attention in the diagnosis of various pathologies in the field of medical research. The specific pattern seen on the finger tip and palmar regions on the hand (dermatoglyphics) of a person are unique and forms a distinctive imprint of an individual. The present paper throws light on various dermatoglyphic patterns reported in(More)
Background: Hernias constitute an important public health problem and often pose a surgical dilemma even for the most skilled surgeons. They are a leading cause of work loss and disability and are sometimes lethal. An early diagnosis and referral to the surgeon should mean short waiting time, elective surgery and a better prognosis. Objectives: 1) To know(More)
Intestinal P-glycoprotein (P-gp) and drug-metabolizing enzymes (DMEs) play an important role in the first-pass-metabolism (FPM) and pharmacokinetics (PK) of majority of drugs. Paracetamol is primarily metabolized by conjugation reactions and a little amount (∼15%) undergoes cytochrome P450 (CYP2E1)-mediated oxidative metabolism produces a hepatotoxic(More)
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