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We apply the zero-one integer programming algorithm described in Karmarkar [12] and Karmarkar, Resende and Ramakrishnan [13] to solve randomly generated instances of the satisfiability problem (SAT). The interior point algorithm is briefly reviewed and shown to be easily adapted to solve large instances of SAT. Hundreds of instances of SAT (having from 100(More)
BACKGROUND Topical life long anti glaucoma medication forms the mainstay of treatment of primary open angle glaucoma. Their long term usage can cause changes in conjunctival epithelium. METHODS Hundred cases of primary open angle glaucoma were divided into four groups of 25 patients each. Each group was put on Timolol, Pilocarpine, Brimonidine and(More)
This paper discusses a new algorithm for solving the assignment problem. This algorithm, called the Approximate Dual Projective algorithm for assignment (ADP/A), is a variant of the Karmarkar interior point algorithm for LPs, specialized to solve the assignment problem. Computational results are reported on various classes of assignment problems. These(More)
We consider the problem of optimizing a quadratic function subject to integer constraints. This problem is NP-hard in the general case. We present a new polynomial time algorithm for computing bounds on the solutions to such optimization problems. We transform the problem into a problem for minimizing the trace of a matrix subject to positive deeniteness(More)
As part of our ongoing structure-activity studies of the vesicular acetylcholine transporter ligand 2-(4-phenylpiperidino)cyclohexanol (vesamicol, 1), 22 N-hydroxy(phenyl)alkyl derivatives of 3 beta-phenyltropane, 6, and 1-methylspiro[1H-indoline-3,4'-piperidine], 7, were synthesized and tested for binding in vitro. Although a few compounds displayed(More)
BACKGROUND To evaluate and compare efficacy and outcome after single site phacotrabeculectomy and conventional combined surgery in cases of coexisting primary open angle glaucoma and cataract. METHODS This prospective study on fifty patients of concurrent primary open angle glaucoma and cataract, who had undergone combined surgery as single site(More)
Phacoemulsification surgery is rapidly emerging as accepted latest surgical technique for the management of cataract. Retrospective analysis of first fifty cases of phacoemulsification surgery performed in our setup were critically evaluated to assess efficacy and adaptability of this procedure in Armed Forces setup. Results of initial twenty five cases(More)