Aniket V Gore

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A central question in the development of multicellular organisms pertains to the timing and mechanisms of specification of the embryonic axes. In many organisms, specification of the dorsoventral axis requires signalling by proteins of the Transforming growth factor-beta and Wnt families. Here we show that maternal transcripts of the zebrafish Nodal-related(More)
The floor plate, a specialized group of cells in the ventral midline of the neural tube of vertebrates, plays crucial roles in patterning the central nervous system. Recent work from zebrafish, chick, chick-quail chimeras and mice to investigate the development of the floor plate have led to several models of floor-plate induction. One model suggests that(More)
During embryonic development, cell type-specific transcription factors promote cell identities, while epigenetic modifications are thought to contribute to maintain these cell fates. Our understanding of how genetic and epigenetic modes of regulation work together to establish and maintain cellular identity is still limited, however. Here, we show that DNA(More)
Smooth muscle cell recruitment is essential for the development of advanced atherosclerotic lesions. Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for SMCs and it is thought to contribute to atherogenesis because PDGF and PDGF receptor b (PDGFRb) are overexpressed in advanced human lesions compared to normal vessels. Intriguingly,(More)
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