Learn More
During embryonic development, cell type-specific transcription factors promote cell identities, while epigenetic modifications are thought to contribute to maintain these cell fates. Our understanding of how genetic and epigenetic modes of regulation work together to establish and maintain cellular identity is still limited, however. Here, we show that DNA(More)
The blood-brain barrier is essential for the proper homeostasis and function of the CNS, but its mechanism of function is poorly understood. Perivascular cells surrounding brain blood vessels are thought to be important for blood-brain barrier establishment, but their roles are not well defined. Here, we describe a novel perivascular cell population closely(More)
Smooth muscle cell recruitment is essential for the development of advanced atherosclerotic lesions. Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for SMCs and it is thought to contribute to atherogenesis because PDGF and PDGF receptor b (PDGFRb) are overexpressed in advanced human lesions compared to normal vessels. Intriguingly,(More)
  • 1