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This work is part of the multi-center Alzheimer's Disease Neuroimaging Initiative (ADNI), a large multi-site study of dementia, including patients having mild cognitive impairment (MCI), probable Alzheimer's disease (AD), as well as healthy elderly controls. A major portion of ADNI involves the use of [(18)F]-fluorodeoxyglucose (FDG) with positron emission(More)
UNLABELLED Accurate, early differentiation of dementias will become increasingly important as new therapies are introduced. Differential diagnosis by standard clinical criteria has limited accuracy. PET offers the potential to increase diagnostic accuracy. (18)F-FDG studies detect metabolic abnormalities in demented patients, but with limited specificity.(More)
This work reports a principal component analysis (PCA)-based approach for reducing bias in distribution volume ratio (DVR) estimates from Logan plots in positron emission tomography (PET). Comparison has been made of all existing bias-removal methods with the proposed PCA method, for both single-estimate PET studies and intervention studies where pre- and(More)
This is the first study to report results from a noninvasive dual-tracer positron emission tomography (PET) in humans not requiring arterial sampling, in which two radiotracers were injected closely in time within the same scan. These studies yield near simultaneous information on two different neuropharmacological systems, providing better characterization(More)
11 C]FMZ tracer molecules (dark blue): blood plasma (red), interstitial space (grey), benzodiazepine receptors on the post-synaptic side (light blue). The synaptic terminals are shown in yellow. Some other possible targets for a radiotracer are pre-synaptic binding sites (green) or pre-synaptic storage vesicles Figure 3.8: Box plot comparisons of the DVR(More)
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