Aniket Arun Kuvalekar

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AIM Inspite of availability of a variety of drugs to treat type 2 diabetes, little is known about their effects on other systems. Normalization of glucose metabolism by these drugs may consequently affect the secretory function in adipocytes. Secretory adipocytokines like adiponectin and leptin are emerging as novel therapeutic targets for type 2 diabetes(More)
A comprehensive in vitro study involving antiglycation, antioxidant and anti-diabetic assays was carried out in mature fruits of strawberry. The effect of aqueous extract of mature strawberry fruits on glycation of guanosine with glucose and fructose with or without oxidizing entities like reactive oxygen species was analyzed. Spectral studies showed that(More)
Long-chain polyunsaturated fatty acids (LCPUFA) i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have established role in the prevention of several diseases like atherosclerosis, cardiovascular disorders, and arthritis. However, LCPUFA sources are limited for availability and acceptability problems of fish and flax oil. Microbial sources of(More)
Rubia cordifolia Linn. a flowering plant species from family Rubiaceae is an important medicinal plant. It is known to have anti-diabetic, antiseptic and antistress properties. In the present paper, antiglycation, antioxidant and antidiabetic activities of roots of Rubia cordifolia Linn. were investigated. Anti-AGE (Advance glycation end products) effect of(More)
OBJECTIVE The present study analyzed the effects of antidiabetic drugs on antioxidant enzymes and liver function test (LFT) markers and their association with homeostatic model assessment of insulin resistance (HOMA-IR) in type 2 diabetic subjects. METHODS We assessed healthy and diabetic subjects (100 each). Diabetic subjects were divided based on(More)
The study was designed to assess the effect of different strawberry extracts on glucose levels, lipid profiles, and oxidative stress in nicotinamide-streptozotocin (NIC-STZ) induced diabetic rats. The associated changes were evaluated through biochemical, molecular, and histological assays. Diabetes was induced by intraperitoneal injection of STZ to albino(More)
Emerging evidence suggests beneficial effects of omega-3 fatty acids on diabetic complications. The present study compared the progressive effects of metformin and flax/fish oil on lipid metabolism, inflammatory markers, and liver and renal function test markers in streptozotocin-nicotinamide-induced diabetic rats. Streptozotocin-induced diabetic rats were(More)
Context • Guduchi Satwa is an Ayurvedic formulation prepared from Tinospora species. It has been used since ancient times to treat liver disorders. Objectives • The study intended to assess the hepatoprotective potential of Satwa prepared from 3 forms of Tinospora against alcohol-induced hepatotoxicity. Design • Male, albino Wistar rats were divided into 6(More)
Omega-3 polyunsaturated fatty acids are essential fatty acids offering multiple health benefits. They form an integral part of cell membrane and are indispensable for normal metabolism. Fish oil and flaxseed oil are among few dietary sources of these fatty acids. In present investigation, hepatoprotective potential of omega-3 fatty acids in the form of(More)
Dyslipidemia is a significant morbidity associated with diabetes and cardiovascular disorders. The present study was undertaken to assess the lipid profile of type 2 diabetic and age-gender matched healthy subjects and its association, if any, with fasting plasma glucose. Clinically diagnosed diabetic subjects were recruited for the study. The fasting(More)