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Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators
TLDR
Two new progesterone receptor ligand binding domain x-ray structures bound to compounds from a structurally related but functionally divergent series, which show different binding modes corresponding to their agonistic or antagonistic nature.
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin
A range of tertiary amines was constructed using a “traceless” linker on a polystyrene resin (REM resin), starting from secondary amines, primary amines, and resin-bound “ammonia”. The methodology is
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
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