Angus R King

Learn More
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. Here we report the generation and(More)
Several nations have adopted hardness-modified copper (Cu) guidelines for protecting freshwater biota. However, there is a lack of good quality data and mechanistic understanding on the effects of true water hardness (calcium (Ca) and magnesium (Mg)) on the bioavailability and toxicity of Cu to freshwater biota, particularly macrophytes. This study(More)
We reported recently that the inflammatory cytokine tumour necrosis factor alpha (TNF-alpha) can upregulate integrin expression, cell attachment and invasion of cells through fibronectin in a human melanoma cell line (HBL). Furthermore, the actions of TNF-alpha were suppressed by the addition of an anti-inflammatory peptide alpha-melanocyte-stimulating(More)
We reported recently that the inflammatory cytokine tumour necrosis factor a (TNF-a) can upregulate integrin expression, cell attachment and invasion of cells through fibronectin in a human melanoma cell line (HBL). Furthermore, the actions of TNF-a were suppressed by the addition of an anti-inflammatory peptide a-melanocyte-stimulating hormone (a-MSH). In(More)
International Society for Technology in Education " Project RED is nothing less than a blueprint for remaking American education. " —Angus King, former governor of Maine " Project RED's research is rich, deep, practical, and meaningful, with the kind of specifics educators require. " —Pamela Livingston, author of 1-to-1 Learning: Laptop Programs That Work(More)
The emphasis on the reduction of gaseous radioactive effluent associated with PET radiochemistry laboratories has increased. Various radioactive gas capture strategies have been employed historically including expensive automated compression systems. We have implemented a new cost-effective strategy employing gas capture bags with electronic feedback that(More)
IMMUNOLOGICAL responses appear to be involved in limiting the extent of some human tumours, and stimulation of this immune response is currently being investi-(fated as a treatment for cancer, both as adjuvant therapy following radical surgery and in advanced disease. Levamisole, Bacille Calmette-Guerin and Coryne-bacterium parvum are all known to stimulate(More)
Lantibiotics are a group of potent antibacterial agents that contain unusual amino acids, such as the thioether amino acids lanthionine and methyllanthionine, and the didehydroamino acids didehydroalanine and didehydro-aminobutyric acid. Here, we report on an antibacterial lantibiotic peptide named SWLP1 (Staphylococcus warneri lantibiotic peptide 1), which(More)
  • 1