Angie M. Y. Shum

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Cancer cachexia is a highly debilitating paraneoplastic disease observed in more than 50% of patients with advanced cancers and directly contributes to 20% of cancer deaths. Loss of skeletal muscle is a defining characteristic of patients with cancer cachexia and is associated with poor survival. The present study reveals the involvement of a myogenic(More)
Cancer cachexia is a highly debilitating paraneoplastic disease observed in more than 50% of patients with advanced cancers and directly contributes to 20% of cancer deaths. Skeletal muscle wasting is a prominent feature of the disease and is believed to result from the loss of balance between protein synthesis and degradation. Quality of life and prognosis(More)
Cancer cachexia is a systemic, paraneoplastic syndrome seen in patients with advanced cancer. There is growing interest in the altered muscle pathophysiology experienced by cachectic patients. This study reports the microarray analysis of gene expression in cardiac and skeletal muscle in the colon 26 (C26) carcinoma mouse model of cancer cachexia. A total(More)
Cardiac and Skeletal Muscles Show Molecularly Distinct Responses to Cancer 1 Cachexia 2 3 Angie M.Y. Shum, David C.Y Fung, Susan M. Corley, Max C. McGill, Nicholas 4 Bentley, Timothy C. Tan, Marc R. Wilkins and Patsie Polly* 5 6 Inflammation and Infection Research Centre and Department of Pathology, New South 7 Wales Systems Biology Initiative, School of(More)
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