Angelos Tsourapas

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OBJECTIVES To identify combinations of tests and treatments to predict and prevent spontaneous preterm birth. DATA SOURCES Searches were run on the following databases up to September 2005 inclusive: MEDLINE, EMBASE, DARE, the Cochrane Library (CENTRAL and Cochrane Pregnancy and Childbirth Group trials register) and MEDION. We also contacted experts(More)
OBJECTIVE To undertake a cost effectiveness analysis comparing first and second generation endometrial ablative techniques, hysterectomy, and the levonorgestrel releasing intrauterine system (Mirena) for treating heavy menstrual bleeding. DESIGN Model based economic evaluation with data from an individual patient data meta-analysis supplemented with cost(More)
OBJECTIVES To establish the clinical effectiveness and cost-effectiveness of structural neuroimaging [structural magnetic resonance imaging (MRI) or computed tomography (CT) scanning] for all patients with psychosis, particularly a first episode of psychosis, relative to the current UK practice of selective screening only where it is clinically indicated.(More)
BACKGROUND Rheumatoid arthritis (RA) is an inflammatory condition that typically causes a symmetrical chronic arthritis. Timely use of disease-modifying antirheumatic drugs (DMARDs) is an essential aspect of disease management, but many patients may not respond even when conventional agents are used optimally. OBJECTIVE To assess the clinical(More)
OBJECTIVES To investigate the role of primary care in the management of HIV and estimate primary care-associated costs at a time of rising prevalence. METHODS Retrospective cohort study between 1995 and 2005, using data from general practices contributing data to the UK General Practice Research Database. Patterns of consultation and morbidity and(More)
OBJECTIVES Programme budgeting and marginal analysis (PBMA) is a priority-setting toolkit which aims to assist decision-makers in identifying the most efficient use of resources. The last systematic literature review on PBMA was published in 2001 and evaluated success in applying PBMA using the criteria of 'reallocation of resources' or the 'setting of(More)
OBJECTIVE The aim of this project was to determine the clinical effectiveness and cost-effectiveness of hysterectomy, first- and second-generation endometrial ablation (EA), and Mirena® (Bayer Healthcare Pharmaceuticals, Pittsburgh, PA, USA) for the treatment of heavy menstrual bleeding. DESIGN Individual patient data (IPD) meta-analysis of existing(More)
OBJECTIVE To investigate the potential cost-effectiveness of alternative 'test-and-treat' strategies in the prevention of spontaneous pre-term birth before 34 and 37 weeks' gestation. DESIGN Model-based economic evaluation. Setting. Clinics, general practices, health centers or any setting delivering antenatal care. POPULATION Asymptomatic women in(More)
alpha1-at phenotypes and serum levels were studied in 100 Greek patients of pulmonary TBC by starch-gel electrophoresis and radial immunodiffusion. The mean value of alpha1-at (315 +/- 77) was significantly lower (p less than 0.005) than in the control group. An attempt is made to explain this finding based on the alpha1-at phenotypes distribution in the(More)