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- John E. Piletz, Feyza AricioÄŸlu, +15 authors Gad M. Gilad
- Drug discovery today
- 2013
Agmatine (decarboxylated arginine) has been known as a natural product for over 100 years, but its biosynthesis in humans was left unexplored owing to long-standing controversy. Only recently has the… (More)
- Gregory A. Ordway, S M Jaconetta, Angelos E. Halaris
- The Journal of pharmacology and experimental…
- 1993
Radioligand binding studies have demonstrated that oxymetazoline has a high affinity for alpha-2A receptors, but lower affinities for alpha-2B and alpha-2C receptors. In contrast, prazosin has high… (More)
- B. E. Jones, Stacey Harper, Angelos E. Halaris
- Brain research
- 1977
The purpose of the present study was to investigate the effects of complete lesions of the noradrenaline locus coeruleus neurons upon wakefulness and paradoxical sleep. Radiofrequency lesions of the… (More)
- John E. Piletz, Angelos E. Halaris, +5 authors C Lindsay Devane
- The world journal of biological psychiatry : the…
- 2009
High levels of pro-inflammatory biomarkers have been reported in depression. In the present study, five pro-inflammatory biomarkers were measured in the blood of patients with major depressive… (More)
- R. Y. Moore, Angelos E. Halaris, B. E. Jones
- The Journal of comparative neurology
- 1978
The ascending projections of serotonin neurons of the midbrain raphe were analyzed in the rat using the autoradiographic tracing method. Axons of raphe serotonin neurons ascend in the ventral… (More)
- Y. Feng, Angelos E. Halaris, John E. Piletz
- Journal of chromatography. B, Biomedical sciences…
- 1997
Decarboxylated arginine, agmatine, is a neurotransmitter candidate for imidazoline receptors. A method is described to measure agmatine in rat brain and human plasma by isocratic high-performance… (More)
- William M. Pitts, W. E. Fann, +4 authors Romani Ilaria
- The Journal of clinical psychiatry
- 1983
In a double-blind, placebo-controlled, variable-dose study of 59 hospitalized nonpsychotic depressed patients, bupropion was significantly (p less than .05 to less than .001) more effective than… (More)
- Meng-Yang Zhu, John E. Piletz, Angelos E. Halaris, Soundar Regunathan
- Cellular and Molecular Neurobiology
- 2003
1. Aims: Agmatine is an endogenous guanido amine and has been shown to be neuroprotective in vitro and in vivo. The aims of this study are to investigate whether agmatine is protective against cell… (More)
- John E. Piletz, Angelos E. Halaris, Deepak Chikkala, Y. Qu
- Journal of psychiatric research
- 1996
Previous studies have indicated that there may be a dysregulation of alpha 2-adrenoceptors and imidazoline receptors in depression. This study compares the effects of chronic antidepressant treatment… (More)
- Anne Clark-Raymond, Angelos E. Halaris
- Journal of psychiatric research
- 2013
Vascular Endothelial Growth Factor (VEGF), initially identified as an angiogenic mitogen, is believed to play a role in hippocampal neurogenesis and response to stress. It exerts neuroprotective… (More)