Angelo Spadaro

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Naproxen is widely used for the treatment of arthritic pain. It can induce gastrointestinal (GI) side effects ranging from stomach irritation to ulceration and bleeding. These complications are believed to be determined from the combined effect of the blockage of prostaglandin biosynthesis in the GI tract and direct action of free carboxylic groups.(More)
OBJECTIVE To evaluate costs, benefits and cost-effectiveness of anti-TNF agents in PsA patients with inadequate response to conventional treatment. METHODS A total of 107 patients, from nine Italian rheumatology centres, with different forms of PsA were given anti-TNF treatment, mainly etanercept (87%). Information on resource use, health-related quality(More)
Synaptic ribbons of the outer plexiform layer in the retina of albino rats are examined, with particular regard to their ultrastructure and to their chronobiological behaviour. As to the ultrastructure, aside from the typical lamellar and granular morphology, synaptic ribbons, whose central bar is roundish and granular, delaminate or furnished with enlarged(More)
Here we provide an extremely simple, rapid, direct, sensitive and specific method to quantify for the first time intracellular GSH in human prostate cancer cells (DU145) and human lung adenocarcinoma cells (A549) using an electrochemical detector coupled to a high performance liquid chromatograph (HPLC-ECD). GSH determination in cancer cells are importance(More)
The aim of the this study was to evaluate the effects of cloricrome, a new coumarin derivative, on dry eye model. Lacrimal gland inflammation-induced dry eye was performed by Concanavalin A (ConA) injection in rabbit, and matrix metalloproteinase-9 (MMP-9), TNFα, IL-1β and IL-8 were evaluated. Tear film integrity was investigated by measuring tear volume(More)
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