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A novel anticancer vaccine candidate built on a nonpeptidic scaffold has been synthesized. Four S-Tn tumor-associated glycomimetic antigens have been clustered onto a calix[4]arene scaffold bearing an immunoadjuvant moiety (P3CS). The immunogenicity of the synthetic construct has been investigated by immunization of mice in vivo. ELISA assay has evidenced(More)
MUC1 protein overexpressed in human epithelial carcinoma is a target in development of novel anticancer vaccines. Multiple units of immunodominant B-cell epitope PDTRP MUC1 core sequence were conjugated to calix[4,8]arene platforms containing TLR2 ligand, to produce two novel anticancer self-adjuvant vaccine candidates. The immunogenicity of the synthetic(More)
The study was designed to investigate the effects of a new ophthalmic solution containing 0.05% vitamin B12 0.05% on corneal nerve regeneration in rats after corneal injury. Eyes of anesthetized male Wistar rats were subjected to corneal injury by removing the corneal epithelium with corneal brush (Algerbrush). After the epithelial debridement, the right(More)
Acetylsalicylic acid (ASA) is the most widely used drug for the prevention of thrombotic risk in the heart, brain and peripheral circulation. Different reports suggest that vitamin E decreases neuronal cell death caused by ischemia and reperfusion in rat models, and influences in vitro antiplatelet effect of aspirin. Unfortunately, ASA causes(More)
Naproxen is widely used for the treatment of arthritic pain. It can induce gastrointestinal (GI) side effects ranging from stomach irritation to ulceration and bleeding. These complications are believed to be determined from the combined effect of the blockage of prostaglandin biosynthesis in the GI tract and direct action of free carboxylic groups.(More)
Here we provide an extremely simple, rapid, direct, sensitive and specific HPLC method to quantify moxifloxacin in rabbit aqueous humor. Separation of moxifloxacin was performed on a Kromasil C8 column using a ternary pre-mixed mobile phase of acetonitrile, methanol and 0.02 M KH 2 PO 4 buffer solution containing 1% triethylamine (pH 3.0 with phosphoric(More)
Here we provide an extremely simple, rapid, direct, sensitive and specific method to quantify for the first time intracellular GSH in human prostate cancer cells (DU145) and human lung adenocarcinoma cells (A549) using an electrochemical detector coupled to a high performance liquid chromatograph (HPLC-ECD). GSH determination in cancer cells are importance(More)
The hypothesis that central analgesia with reduced side effects is obtainable by occupying an 'allosteric' site in the MOR ligand binding domain requires the development of new ligands with peculiar pharmacological profile to be used as tools. New benzomorphan derivatives, analogues of LP1, a multitarget MOR agonist/DOR antagonist, were designed to examine(More)
The aim of the this study was to evaluate the effects of cloricrome, a new coumarin derivative, on dry eye model. Lacrimal gland inflammation-induced dry eye was performed by Concanavalin A (ConA) injection in rabbit, and matrix metalloproteinase-9 (MMP-9), TNFα, IL-1β and IL-8 were evaluated. Tear film integrity was investigated by measuring tear volume(More)
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