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NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression
The findings suggest that the role of MAO A in pathological aggression may be mediated by changes in NMDAR subunit composition in the PFC, and point to a critical function of this receptor in the molecular bases of antisocial personality. Expand
Regional distribution of 5α-reductase type 2 in the adult rat brain: An immunohistochemical analysis
Findings show that, in the adult brain, 5αR2 is distributed in critical regions for behavioral regulation, suggesting that the functional role of this isoform is present throughout the entire lifespan of the individual. Expand
Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones.
The findings provide biochemical evidence for sex- and hormone- dependent differences in the density and function of CB1 receptors in selected brain regions, and in behaviours associated with greater vulnerability to drug addiction, revealing a more vulnerable behavioural phenotype in female than in male rats. Expand
Characterization of COR627 and COR628, Two Novel Positive Allosteric Modulators of the GABAB Receptor
Two novel compounds, COR627 and COR628, may represent two additional tools for use in investigating the roles and functions of positive allosteric modulatory binding sites of the GABAB receptor. Expand
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor.
Although displaying a lower potency in vitro than the reference compound GS39783, the new compounds 6, 10, and 11 exhibited a higher efficacy in vivo: combination of these compounds with a per se nonsedative dose of baclofen resulted in shorter onset and longer duration of the loss of righting reflex in mice. Expand
The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake.
Findings suggest that the behavioral deficits associated with low MAO-A activity may reflect developmental alterations of 5-HTT within5-HTergic neurons. Expand
Δ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
Results indicate that Δ9-THC reduces METH-induced brain damage via inhibition of nNOS expression and astrocyte activation through CB1-dependent and independent mechanisms, respectively. Expand
D 9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microgliaExpand