Angelique Y. Louie

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First-generation systems that combine these two techniques have been developed offering new opportunities for integrated structural-functional imaging in vivo. ABSTRACT | A number of laboratories and companies are currently exploring the development of integrated imaging systems for magnetic resonance imaging (MRI) and positron emission tomography (PET).(More)
Magnetic resonance imaging (MRI) has become one of the most important diagnosis tools available in medicine. Typically MRI is not capable of sensing biochemical activities. However, recently emerged activatable MRI contrast agents (CAs), whose relaxivity is variable in response to a specific parameter change in the surrounding physiological(More)
BACKGROUND Plaque vulnerability to rupture has emerged as a critical correlate to risk of adverse coronary events but there is as yet no clinical method to assess plaque stability in vivo. In the search to identify biomarkers of vulnerable plaques an association has been found between macrophages and plaque stability--the density and pattern of macrophage(More)
The recent emergence of multimodality imaging, particularly the combination of PET and MRI, has led to excitement over the prospect of improving detection of disease. Iron oxide nanoparticles have become a popular platform for the fabrication of PET/MRI probes owing to their advantages of high MRI detection sensitivity, biocompatibility, and(More)
We describe an innovative program at the University of California, Davis for students to engage in clinical needs finding. Using a team-based approach, students participated in clinical rotations to observe firsthand the needs of clinicians at the university affiliated medical center. The teams were asked to develop documentary-style videos to capture key(More)
Photoswitchable spiropyran has been conjugated to the crowned ring system DO3A, which improves its solubility in dipolar and polar media and stabilizes the merocyanine isomer. Adding the lanthanide ion gadolinium(III) to the macrocyclic ring system leads to a photoresponsive magnetic resonance imaging contrast agent that displays an increased spin-lattice(More)
We are honored and pleased to present the Special Issue on Biomedical Engineering in the University of California System. Through the years, we have been fortunate enough to learn first-hand about our col-leagues' exciting areas of research at the Annual UC Systemwide Bioengineering Symposia and wanted to give you a glimpse of the cutting-edge research(More)
The electronic conductivity of tri-n-octylphosphineoxide (TOPO)-protected CdSe quantum dots (QDs) was studied at the air-water interface using the Langmuir technique within the context of photochemical and photophysical excitation. It was found that, upon photoirradiation with photon energies higher than that of the absorption threshold, the voltammetric(More)
Introduction Biomedical imaging is experiencing a very rapid expansion, with new technologies enabling improvements in spatial and temporal resolution and sensitivity to small changes, resulting in high-quality maps of structural and functional events. The clinical impact of imaging technologies is profound, with more than one hundred million studies(More)
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