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Synthetic lethal screen identification of chemosensitizer loci in cancer cells
TLDR
It is shown that several of these targets sensitize lung cancer cells to paclitaxel concentrations 1,000-fold lower than otherwise required for a significant response, and mechanistic relationships between cancer-associated aberrant gene expression programmes and the basic cellular machinery required for robust mitotic progression are identified.
Cause and consequence of cancer/testis antigen activation in cancer.
TLDR
The history of the CTA field is reviewed and recent findings indicating that CTAs can play functional roles in supporting tumorigenesis are presented.
ERK2 enters the nucleus by a carrier-independent mechanism
TLDR
It is suggested that GFP-ERK2 enters the nucleus by a saturable, facilitated mechanism, distinct from a carrier- and energy-dependent import mechanism and involves a direct interaction with nuclear pore complex proteins.
Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1*
TLDR
The use of a yeast two-hybrid screen to identify point mutations in ERK2 that impair its interaction with MEK1/2, yet do not alter its interactions with other proteins suggests an essential role for the MAP kinase insert and residues within or just preceding α-helix G in the interaction of ERk2 with MEk1/ 2.
The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions*
TLDR
Results suggest that PEA-15 sequesters ERK2 in the cytoplasm at least in part by interfering with its ability to interact with nucleoporins, presenting a potential paradigm for regulation of ERK 2 localization.
Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer
TLDR
A multidimensional functional genomics approach is implemented that incorporates 7 different phenotypic assays in 11 distinct disease settings and discovers that Foetal and Adult Testis Expressed 1 (FATE1) is a key survival factor in multiple oncogenic backgrounds.
Stimulus-Coupled Spatial Restriction of Extracellular Signal-Regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-Response Pathways
TLDR
The capacity of active ERK1/2 to accumulate in the nucleus and drive immediate-early gene expression is dependent upon the nature of the inductive signal, but independent of the amplitude of ERK 1/2 activation, which means nuclear accumulation of active EMT is a discrete regulated step that can direct the function of the kinase in response to specific stimuli.
Mutations in ERK2 Binding Sites Affect Nuclear Entry*
TLDR
The results of import reconstitution assays support the idea that direct interactions with nucleoporins are involved in ERK2 nuclear entry and that multiple events contribute to the ligand-dependent relocalization of these protein kinases.
p115 Rho GTPase activating protein interacts with MEKK1
TLDR
A novel interaction is discovered with p115 Rho GTPase‐activating protein (GAP) that offers a connection between this protein kinase and the machinery regulating cytoskeletal reorganization.
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