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A new system for complete automated sleep analysis has been developed (Somnoscript2000). Eighteen healthy young volunteers (ages 21-28 years, 9 females and 9 males) underwent a complete polysomnographic (PSG) registration. EEG from 17 electrode positions was recorded simultaneously with the polygraphic parameters (CATEEM(R)). The characterization of the(More)
Sleep in humans is classically assessed by recording a multichannel electroencephalogram (EEG) in connection with an electrooculogram (EOG) and an electromyogram (EMG). In general, human sleep is manually staged into 6 categories (from awake through REM sleep to stage 4 reflecting deep sleep) on the basis of a visual inspection of EEG periods (epochs) of 20(More)
This clinical trial was designed to evaluate the efficacy of the external nasal dilator Breathe Right (nasal strip) on snoring. The assessment of snoring intensity and duration as well as the sleep quality without the Breathe Right nasal strip and after application was performed in 30 out-patients with primary habitual snoring. An all-night polysomnographic(More)
Effects of repeated twice daily i.p. administration of haloperidol (0.5 mg/kg), clozapine (3.0 mg/kg) and prothipendyl (1.0 mg/kg) on spontaneous A9 and A10 cell activity were studied using extracellular multiunit recording in rats, which offers relatively rapid access to neural activity in a large number of cells. Two cell types were identified, which(More)
In a double-blind placebo-controlled psychopharmacological study 263 patients with cognitive impairment were screened and 137 of them were selected (following defined inclusion and exclusion criteria) to participate in a clinical trial (for results of treatment phase see part II, in preparation). The pretreatment state was evaluated twice using(More)
The aim of this randomized, double-blind, placebo-controlled 16-week study was to investigate the clinical efficacy of cyclandelate (Natil, 1,600 mg/day) in 139 adult outpatients with cognitive impairment (70 allocated to cyclandelate; 69 to placebo). Quantitative-topological EEG, event-related potentials (P300) and psychophysiological interview-based(More)
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