Angelika Kühnle

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Stereochemistry plays a central role in controlling molecular recognition and interaction: the chemical and biological properties of molecules depend not only on the nature of their constituent atoms but also on how these atoms are positioned in space. Chiral specificity is consequently fundamental in chemical biology and pharmacology and has accordingly(More)
Enantiospecific adsorption of cysteine molecules onto chiral kink sites on the Au(110)-(1x2) surface was observed by scanning tunneling microscopy. l- and d-cysteine dimers were found to adopt distinctly different adsorption geometries at S kinks, which can be understood from the need to reach specific, optimum molecule-substrate interaction points.(More)
Colloidal suspensions are susceptible to gravitationally induced phase separation. This can be mitigated by the formation of a particle network caused by depletion attraction. The effectiveness of this network in supporting the buoyant weight of the suspension can be characterized by its compressional modulus. We measure the compressional modulus for(More)
Calcite (CaCO3) is one of the most abundant minerals on earth and plays an important role in a wide range of different fields including, for example, biomineralization and environmental geochemistry. Consequently, surface processes and reactions such as dissolution and growth as well as (macro)molecule adsorption are of greatest interest for both applied as(More)
Calcite, the most stable polymorph of calcium carbonate, is one of the most abundant simple salts in the geological environment. Consequently, its natural (1014) cleavage plane has been studied extensively by a wide range of surface-sensitive techniques, giving indications for two reconstructions, namely a (2 × 1) and a so-called 'row-pairing'(More)
Calcite is a mineral of fundamental importance that plays a crucial role in many fields of research such as biomineralization, biomolecule adsorption, and reactivity as well as industrial and daily life applications. Consequently, the most stable cleavage plane of calcite has been studied extensively using both direct imaging techniques such as atomic force(More)
Pharmacokinetics were studied in relation to hepatic side-effects in 20 patients (19 adults aged 18-53 years and one child of 11 years) undergoing BMT after conditioning with 1 mg/kg busulfan (every 6 hours for 16 doses). Busulfan was quantitated in plasma samples at 10 time points within the 6 h dosing interval using HPLC before and after dose numbers 1,(More)
The interaction of largish molecules with metal surfaces has been studied by combining the imaging and manipulation capabilities of the scanning tunneling microscope (STM). At the atomic scale, the STM results directly reveal that the adsorption of a largish organic molecule can induce a restructuring of a metal surface underneath. This restructuring(More)
Non-contact atomic force microscopy is used to study C(60) molecules deposited on the rutile TiO(2)(110) surface in situ at room temperature. At submonolayer coverages, molecules adsorb preferentially at substrate step edges. Upon increasing coverage, ordered islands grow from the decorated step edges onto the lower terraces. Simultaneous imaging of(More)
The self-assembly of monodispersed supramolecular nanoclusters was observed by scanning tunneling microscopy (STM). The clusters form from the naturally occurring amino acid cysteine by vapor deposition onto the Au(110)-(1 x 2) surface under ultrahigh vacuum conditions. Enantiomerically pure l- and d-cysteine yields clusters with mirror-image STM(More)