Angelika Goertzen

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Valproic acid (VPA)-induced encephalopathy is a rarely considered side effect, with somnolence, reduced motor activity and severe deterioration of cognitive and behavioural abilities. In accordance with the increasing clinical importance of valproate clinical symptoms, causes and possibilities of treatment are reviewed by reporting on two cases of(More)
We used immunocytochemical staining of peripheral (trigeminal) nerve to screen sera of patients with Guillain-Barré syndrome (GBS) for the presence of autoantibodies, using sera from patients with other neurological diseases and healthy volunteers as controls. Most sera mildly reacted with axons, myelin sheaths, or sensory neurons without correlation to a(More)
Recurrent back pain and leg monoparesis in a 38 year old woman could be traced back to a focus of intraspinal endometriosis. Upon admission, neurological examination revealed multiple sensory deficits and a proximal spastic paresis of the left leg. The patient complained about backache, which spontaneously disappeared some days later. History taking(More)
Introduction. Lyme neuroborreliosis is a nervous system infection caused by spirochete Borrelia burgdorferi with diverse neurological complications. Stroke due to cerebral vasculitis is a rare consequence of neuroborreliosis and has been described in just a few case reports. Case Presentation. Here, we report the case of a 43-year-old patient who presented(More)
Sir, We have read with great interest the McGonigal et al. (2010) article, which addresses the pathogenic role of GD1a antibodies and complement activation for node of Ranvier dysfunction. Nodal injury might explain several electrophysiological features and clinical symptoms in patients with Guillain–Barré syndrome including the sometimes rapid recovery(More)
Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterized example of a psychosyndrome, and(More)
Guillain-Barré syndrome (GBS) is an autoimmune disease with progressive flaccid paralysis of the extremities. Several auto-antibodies have been identified, binding to myelin, gangliosides, astrocytes or proteins at the nodes of Ranvier. Some epitopes are not confined to the peripheral nerve, suggesting that auto-antibodies may also contribute to symptoms of(More)
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