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Glioblastoma is the most malignant tumor in the range of cerebral astrocytic gliomas. A lot of experimental models are used to evaluate various properties of glioblastoma. Chicken chorioallantoic membrane model is one of them. OBJECTIVE. To evaluate histology and survival of glioblastoma tumors taken immediately from operating theatre and transplanted on(More)
The role of hypoperfusion in cases of sudden cardiac death of young athletes is discussed. The coronary index, a ratio of the coronary caliber and the myocardial mass, was estimated from postmortem coronary angiograms. The coronary index reflects the degree of myocardial blood supply. In each case, a decrease in the coronary index, in combination with(More)
In vitro fertilization technology consists of the selection and fertilization of oocytes, the production and transplantation of embryos to recipients. The quality of oocytes has a direct impact on the fertilization and developmental competence of oocytes. Criteria that show the quality of oocytes are subdivided into morphological, cellular, and molecular.(More)
In the study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in mice has been evaluated. BALB/c mice (n = 120; 4-6 weeks old, both sexes) were used in the following groups: 1) urethane-treated, 2) urethane-NaVP-treated, 3) only NaVP-treated, 4) control. In the same groups, castrated male mice (n = 48) were investigated.(More)
Between 1998 and 2001 thirty-five patients underwent osteochondral transplantation (mosaicplasty) and 35 patients (controls) - microfracture procedure for osteochondral or chondral knee joint pathology treatment. Average age of patients was 24.74+/-7.20 years. Patients were evaluated through International Cartilage Repair Society (ICRS) and modified(More)
It is believed that neurons are generated near the surface of the embryonic cerebral ventricles, whereas glial cell proliferation occurs at sites distant to the ventricles. There is still uncertainty concerning the developmental stages when glial and neuronal cell lines diverge in the proliferative zone. The purpose of this study was to determine whether at(More)
In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated. BALB/c mice (n = 60; 4-6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control. In the same groups, ovariectomized female mice (n = 60)(More)
OBJECTIVE The aim of this study was to examine and evaluate morphometrically age-related changes in collagen network in the tunica media of human basilar artery. MATERIALS AND METHODS Histological analysis of the basilar arteries obtained from 89 individuals, aged 20 to 85 years, was performed. The study has been carried out by standard histological(More)
Glioblastoma is the most common brain malignancy and is marked by an extremely poor prognosis, despite advances in surgical and clinical neuro-oncology. That is why central nervous system glioblastoma is quite a challenging neoplasm, requiring much further research to understand the molecular and cellular clinical basis. Existing in vivo glioblastoma models(More)
Sodium valproate (VPA) was shown to inhibit cell growth mechanisms such as cell cycle arrest, proliferation suppression, increase of apoptosis. Many aspects of the contribution of the VPA pharmacological mechanisms and their significance in gender-related processes have not been investigated. In our study, we have tested hypothesis that the influence of VPA(More)