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Lesions to the lateral parabrachial nucleus (PBN), one of the subnuclei that make up the pontine parabrachial complex, impairs the acquisition of taste aversion learning (TAL) with LiCl as the toxic stimulus. In this experiment, PBNl-lesioned and control rats were trained to learn a delayed task with a 15-min interval between presentation of the gustatory(More)
The research about the neural basis of taste aversion learning (TAL) has pointed out the area postrema (AP) as a fundamental structure implied in the processing of certain toxic stimuli. Likewise, recent studies demonstrated that electric stimulation of the AP is an efficient substitute of the aversive stimulus. The lateral parabrachial nucleus (PBN1), one(More)
The effect of medullary afferent vagal axotomy on NaCl-induced short-term and long-term taste aversion learning (TAL) was examined to assess the relevance of the vagus nerve in drug-induced TAL. The results show that medullary afferent vagal axotomy disrupts NaCl-induced short-term (nondelayed) TAL, while having no effect on learning acquired with the same(More)
This series of experiments demonstrates a functional dissociation between the area postrema (AP) and the vagus nerve in short-term taste aversion learning (TAL). Although medullary axotomy of the afferent component of the vagus disrupted the learning observed with NaCl-induced short-term (nondelayed) TAL, lesioning the AP failed to interfere with the(More)
It has been recently shown that Roman high- (RHA) and low- (RLA) avoidance rats show behavioural divergence in successive negative contrast (SNC) induced in one-way avoidance learning [Torres C, Cándido A, Escarabajal MD, de la Torre L, Maldonado A, Tobeña A, et al. Successive negative contrast effect in one-way avoidance learning in female roman rats.(More)
Research into the neural mechanisms involved in the acquisition of learned aversions induced by drug points toward the area postrema (AP) as one of the structures implicated in the detection of drug aversive consequences. The evidence suggest that although the AP is indeed involved in drug-induced learned aversions, its functional integrity is not always a(More)
The vagus nerve has been proposed in numerous studies as one of the peripheral mechanisms involved in drug-induced taste aversion learning, although available data have been controversial. The differential results obtained in the present series of experiments with vagotomy and NaCl-induced short-term and long-term aversion learning suggest that the vagal(More)
The structural characteristics of the area postrema, its anatomical connections, participation in the detection of emesis-provoking substances and the effects of area postrema lesions on taste aversion learning acquisition, are all factors which speak in favor of a role as a chemoreceptor zone involved in the detection of aversive agents which act as(More)
Existing data on the effects of area postrema (AP) lesions on body rotation-induced emesis as well as on the participation of this zone in the acquisition of taste aversion learning (TAL) with other emetic agents suggest a possible role for the AP in learned aversions induced by body rotation. Nevertheless, earlier studies have shown that AP lesions do not(More)
The functional meaning of the visceral information processing in the medial parabrachial nucleus (PBNm) was analyzed in this study through a short-term aversion learning task. In this short-term task the animals (Wistar rats) had to learn to discriminate between two different gustatory-olfactory stimuli presented simultaneously (two graduated burettes); one(More)