Angela Zellmer

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Serum concentrations of progesterone begin to rise just before the midcycle gonadotropin surge that leads to ovulation. To examine the role of progesterone in the regulation of these events, we evaluated the effects of a low dose (1 mg/day, orally) of the antiprogesterone RU 486 on the timing of the gonadotropin surge and ovulation in normally cycling(More)
OBJECTIVE Our objective was to determine if a progesterone antagonist might interdict the development of a secretory endometrium. STUDY DESIGN Eleven normally cycling women not at risk for pregnancy received RU 486 (1 mg/day orally) or placebo throughout one menstrual cycle in a randomized, double-blind, crossover fashion. Estradiol, progesterone, and(More)
OBJECTIVE To investigate whether the antiprogestin RU486 acts primarily on the hypothalamus to delay the midcycle gonadotropin surge and thus gain insight into the site(s) of action of P in the control of ovulation. DESIGN Prospective, crossover, single-blinded clinical study. SETTING Outpatient clinic in an academic research environment. PATIENTS(More)
OBJECTIVE To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging. DESIGN Prospective controlled clinical study. SETTING Normal human volunteers in an academic research institution. SUBJECTS Women with regular menstrual cycles. INTERVENTIONS Thirty-two women, aged 20 to(More)
OBJECTIVE To investigate whether luteal and endometrial abnormalities occur more frequently in an infertile population and thus contribute to infertility. DESIGN Prospective controlled clinical study. SETTING Outpatient clinic in an academic research institution. PARTICIPANTS Thirty-three fertile controls and 31 infertile women without ovulatory(More)
Levels of soluble Axl (sAxl) are routinely assessed in human sera by sandwich enzyme-linked immunosorbent assay (ELISA). Although sAxl values are suggested to diagnose different types of disorders, no uniform ELISA method is available, allowing the reliable interassay comparison between results. Furthermore, little is known about the stability of sAxl under(More)
OBJECTIVE Our purpose was to investigate the diagnostic accuracy of single or summed measurements of progesterone and placental protein 14, a progestin-dependent endometrial glycoprotein, in the evaluation of luteal function. STUDY DESIGN Forty-five healthy women had daily blood measurements of luteinizing hormone, progesterone, and placental protein 14(More)
Early diagnosis is the key for the successful treatment of breast cancer. A serum marker for the early detection of breast cancer could significantly reduce breast cancer morbidity and mortality by bringing the time of diagnosis at an earlier and therefore still curable stage. So far, no biomarker for the early detection is available for the clinical(More)
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