Angela Wisniewski

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CONTEXT Recent interventional studies indicate that post-menopausal hormone replacement therapy is associated with an increased risk of cardiovascular mortality and breast cancer. Isoflavones, a class of plant estrogens, have structural similarities to estradiol. Hence, isoflavones may exert beneficial estrogenic health effects in postmenopausal women with(More)
Human immunodeficiency virus (HIV)-infected individuals often demonstrate neuropsychiatric impairment; however, it is unclear how brain metabolism may be altered in such patients. We used in vivo phosphorus 31 magnetic resonance spectroscopy to noninvasively assess brain energy and phospholipid metabolism by measuring brain concentrations of adenosine(More)
BACKGROUND Cerebral injury is among the most common and disabling complications of open heart surgery. Attempts to provide neuroprotection have yielded conflicting results. We assessed the potential of propofol-induced burst suppression during open heart surgery to provide cerebral protection as determined by postoperative neuropsychologic function. (More)
OBJECTIVE To determine if asthma control improves in patients who receive physician-pharmacist collaborative management (PPCM) during visits to primary care medical offices. DESIGN Prospective pre-post study of patients who received the intervention in primary care offices for 9 months. The primary outcome was the sum of asthma-related emergency(More)
BACKGROUND The comparative efficacy of adalimumab (ADA) and infliximab (IFX) in Crohn's disease, and the benefit of initial combotherapy with an immunomodulator, are debated. AIM To assess the best anti-TNF treatment regimens in Crohn's disease. METHODS We included 906 biologic-naïve Crohn's disease patients [median age, 31 years (24-41)] and performed(More)
OBJECTIVES Abnormalities of liver function tests were been reported in adults with TS and in patients with oestrogen replacement therapy. DESIGN The aim of this study was to evaluate the prevalence of liver disease in patients before or with oestrogen therapy. MATERIALS 79 patients, aged 13(2/12) to 60(4/12), for oestrogen replacement therapy: 13--with(More)
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