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First-in-human neuroepigenetic PET imaging with [11C]Martinostat reveals conserved region-specific expression of class I HDACs in the healthy brain. Brain epigenetics revealed Certain enzymes called… Expand
Frontotemporal dementia (FTD) arises from neurodegeneration in the frontal, insular, and anterior temporal lobes. Autosomal dominant causes of FTD include heterozygous mutations in the GRN gene… Expand
Frontotemporal dementia (FTD) is a presenile dementia presenting with a variety of clinical phenotypes arising from Frontotemporal Lobar Degeneration (FTLD), a family of neurodegenrative pathologies… Expand